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MABC640 Anti-MUM1 Antibody, clone 4G10

Detect Mutated melanoma-associated antigen 1 using this mouse monoclonal antibody, Anti-MUM1 Antibody, clone 4G10 validated for use in western blotting & IHC.

Anti-MUM1 Antibody, clone 4G10 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: MUM-1, EXPAND1, MUM1 UniProt Number: Q2TAK8
MABC640
100 µL  
Purchase on Sigma-Aldrich

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概述

Replacement Information

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCMAscitesMonoclonal Antibody
Description
Catalogue NumberMABC640
DescriptionAnti-MUM1 Antibody, clone 4G10
Alternate Names
  • PWWP domain-containing protein MUM1
  • Mutated melanoma-associated antigen 1
  • MUM-1
  • Protein expandere
Background InformationMutated melanoma-associated antigen 1 (MUM1), also known as Protein expandere and PWWP domain-containing protein MUM1. MUM1’s normal role is as a DNA and chromatin associated protein that is involved in the cell’s response to DNA damage. It is driven to DNA breaks by its interaction with another DNA chromatin protein, TP53BP1, which it binds. The binding facilitates chromatin relaxation and entry of DNA repair enzymes. MUM1 is required for efficient DNA repair and cellular survival after DNA damage. Interestingly MUM1 was first identified by cloning the chromosomal breakpoints of a multiple myeloma cell line and was identified as a member of the interferon response transcriptional factor gene family (IFR). MUM1 appears to play a critical role in cell proliferation, differentiation and survival of various cancers, as well as monocytes and dendritic cells. MUM1 is expressed in B cells and plasma cells as well and in some populations of T lymphocytes. EMD-Millipore’s Anti-MUM1 mouse monoclonal antibody has been tested in against recombinantly expressed human MUM1 protein and in paraffin embedded immunohistochemistry on human melanoma, non-Hodgkin’s lymphoma and normal uterus tissue sections.
References
Product Information
FormatAscites
Control
  • Recombinant MUM1 protein
PresentationMouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Mutated melanoma-associated antigen 1 using this mouse monoclonal antibody, Anti-MUM1 Antibody, clone 4G10 validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected MUM1 in human uterus, melanoma, and non-Hodgkin`s lymphoma tissues.

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenPurified recombinant fragment of human MUM1 expressed in E. Coli.
Clone4G10
HostMouse
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Gene Symbol
  • MUM-1
  • EXPAND1
  • MUM1
Purification MethodUnpurified
UniProt Number
Molecular Weight~55 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in recombinant MUM1 protein.

Western Blotting Analysis: A 1:500-2000 dilution of this antibody detected recombinant MUM1.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
MABC640 04053252914393