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MABE1153-25UG Anti-MRE11 Antibody, clone 15B8.1E7.6

Anti-MRE11, clone 15B8.1E7.6 , Cat. No. MABE1153-25UG, is a highly specific armenian hamster monoclonal antibody, that targets Double-strand break repair protein MRE11A and has been tested in Western Blotting.

Anti-MRE11 Antibody, clone 15B8.1E7.6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Gene Symbol: Mre11a, Mre11 UniProt Number: Q61216
MABE1153-25UG
25 μg  
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWBAHmPurifiedMonoclonal Antibody
Description
Catalogue NumberMABE1153-25UG
DescriptionAnti-MRE11 Antibody, clone 15B8.1E7.6
Alternate Names
  • Double-strand break repair protein MRE11A
  • MmMRE11A
  • Meiotic recombination 11 homolog 1
  • MRE11 homolog 1
  • Meiotic recombination 11 homolog A
  • MRE11 homolog A
Background InformationDouble-strand break repair protein MRE11A (UniProt: Q61216; also known as MmMRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A) is encoded by the Mrer11a (also known as Mre11) gene (Gene ID: 17535) in murine species. MRE11A a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. It localizes to discrete nuclear foci after treatment with genotoxic agents. MRE11A is a component of the MRN complex that possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11A forms a complex with the RAD50 homolog, which is required for non-homologous joining of DNA end. RAD50 may be required to bind DNA ends and hold them in close proximity, which facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. In conjunction with a DNA ligase, MRE11A is reported to promote the joining of non-complementary ends in vitro using short homologies near the ends of the DNA fragments.
References
Product Information
FormatPurified
PresentationPurified armenian hamster monoclonal antibodyIgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-MRE11, clone 15B8.1E7.6 , Cat. No. MABE1153-25UG, is a highly specific armenian hamster monoclonal antibody, that targets Double-strand break repair protein MRE11A and has been tested in Western Blotting.
Key Applications
  • Western Blotting
Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected MRE11 in 10 µg of mouse embryo fibroblast cell lysate (MEFs).
Biological Information
ImmunogenRecombinant fragment corresponding to 540 amino acids from murine Double-strand break repair protein MRE11A.
ConcentrationPlease refer to lot specific datasheet.
HostArmenian Hamster
SpecificityClone 15B8.1E7.6 detects Double-strand break repair protein MRE11A in human and murine cells.
IsotypeIgG
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteHuman, Mouse.
Antibody TypeMonoclonal Antibody
Gene Symbol
  • Mre11a
  • Mre11
Purification MethodProtein G purified
UniProt Number
Molecular Weight80 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Ramo cell lysate.
Western Blotting Analysis: 4 µg/mL of this antibody detected MRE11 in 10 µg of Ramo cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
MABE1153-25UG 04054839447969