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ABE206 Anti-MLL2 (C-Term) Antibody

Detect MLL2 (C-Term) using this Anti-MLL2 antibody (C-Term) validated for use in western blotting & IHC.

Anti-MLL2 (C-Term) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones Gene Symbol: KMT2D, ALR, MLL2, MLL4 UniProt Number: O14686
ABE206
100 µg  
Purchase on Sigma-Aldrich

特卖

概述

Replacement Information

特卖

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE206
DescriptionAnti-MLL2 (C-Term) Antibody
Alternate Names
  • Histone-lysine N-methyltransferase 2D
  • Lysine N-methyltransferase 2D
  • ALL1-related protein
  • Myeloid/lymphoid or mixed-lineage leukemia protein 2
Background InformationMLL2, also known as Histone-lysine N-methyltransferase 2D, or Lysine N-methyltransferase 2D or ALL1-related protein, or Myeloid/lymphoid or mixed-lineage leukemia protein 2, and encoded by the gene KMT2D/ALR/MLL2/MLL4, is a histone methyltransferase that methylates Lys-4 of histone H3 to form H3K4me. H3K4me represents a specific tag for epigenetic transcriptional activation and for instance in estrogen receptor function where MLL2 acts as coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2 is also a component of the ASCOM/Mll2/3 complex which plays an important role during development particularly in lymphomagenesis. MLL2 is localized to the nucleus. MLL2 is expressed in most embryonic and adult tissues. Defects in MLL2 are associated with Kabuki syndrome, a congenital mental retardation syndrome with additional features, including postnatal dwarfism, facial and bone deformities. Defects are also associated with medulloblastoma a highly malignant primary brain tumor.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect MLL2 (C-Term) using this Anti-MLL2 antibody (C-Term) validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected MLL2 (C-term) in human breast cancer tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human MLL2 (C-term).
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • KMT2D
  • ALR
  • MLL2
  • MLL4
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~75 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human testis tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MLL2 (C-term) in 10 µg of human testis tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABE206 04053252944642

Documentation

Anti-MLL2 (C-Term) Antibody MSDS

职位

物料安全数据表 (MSDS) 

Anti-MLL2 (C-Term) Antibody 分析证书

标题批号
Anti-MLL2 (C-Term) - 3807978 3807978
Anti-MLL2 (C-Term) - Q2361576 Q2361576
Anti-MLL2 (C-Term) -2686110 2686110
Anti-MLL2 (C-Term) -2806494 2806494
Anti-MLL2 (C-Term) Polyclonal Antibody 3050674
Anti-MLL2 (C-Term) Polyclonal Antibody 2909629

参考

参考概述公共医疗ID
Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon.
Natarajan, Thanemozhi G, et al.
Cancer Cell Int., 10: 13 (2010)  2010

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