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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABT356 Sigma-AldrichAnti-Integrin alpha6 Antibody, clone 6H7.1

This Anti-Integrin alpha6 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Integrin alpha6.

Anti-Integrin alpha6 Antibody, clone 6H7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
技术信息

Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: ITGA6 UniProt Number: P23229

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IH(P)	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABT356
Description	Anti-Integrin alpha6 Antibody, clone 6H7.1
Alternate Names	Integrin alpha-6 CD49 antigen-like family member F VLA-6 CD49f
Background Information	Integrin alpha-6 (UniProt P23229; also known as CD49 antigen-like family member F, CD49f, Integrin alpha6B, VLA-6) is encoded by the ITGA6 (also known as ITGA6B) gene (Gene ID 3655) in human. The biological functions attributed to cell-extracellular matrix (ECM) interactions are mediated primarily by integrin family transmembrane receptors. A total of 18 alpha and 8 beta integrins have been identified in human. Each alpha integrin pairs up with one beta integrin non-covalently to form a functional heterodimeric dimer. At least 24 distinct integrin heterodimers are known with varying ligand specificities. For example, the alpha6-beta1 integrin is reported to mediate the spreading and laminin-binding of Schwann cells, while the alpha6-beta4 integrin is shown to play a role in the suppression of anoikis in human intestinal epithelial cells (IECs). Signal (1-23), Integrin alpha-6 (24-1130). Processed into Integrin alpha-6 heavy chain (24 – 938), Integrin alpha-6 light chain (942-1130), Processed integrin alpha-6 (Alpha6p; 636 – 1130)

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-Integrin alpha6 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Integrin alpha6.
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Integrin alpha6 in human skin tissue.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to the cytoplasmic region of human Integrin alpha6 isoforms 2/4/6/7/9.
Epitope	Cytoplasmic region of isoforms 2/4/6/7/9
Clone	6H7.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Expected to react with Integrin alpha-6 spliced isoforms 2 (Alpha-6X1A), 4 (Alpha-6X2A ), 6 (Alpha-6X1X2A), 7, and 9, as well as their respective proforms, cleaved light chains, and processed integrin alpha-6 forms (Alpha6p). Epitope is not present in isoform 1 (Alpha-6X1X2B), 3 (Alpha-6X1B), or 5 (Alpha-6X2B).
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000201
Gene Symbol	ITGA6
Purification Method	Protein G Purified
UniProt Number	P23229
Molecular Weight	~140 kDa observed. Due to glycosylation, the target band(s) appears larger than the calculated 106.6 to 124.0 kDa based on the proform sequences of isoforms 2/4/6/7/9. Uncharacterized band(s) may appear in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in SW480 human colon cancer cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Integrin alpha6 in 10 µg of SW480 human colon cancer cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABT356	04055977277036

Documentation

Anti-Integrin alpha6 Antibody, clone 6H7.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-Integrin alpha6 Antibody, clone 6H7.1 分析证书

标题	批号
Anti-Integrin alpha6, clone 6H7.1 - 3330363	3330363
Anti-Integrin alpha6, clone 6H7.1 - 4069737	4069737
Anti-Integrin alpha6, clone 6H7.1 -Q2595862	Q2595862

技术信息

标题
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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