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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABS1301 Sigma-AldrichAnti-IGF-IRα subunit Antibody, clone 1B1

This Anti-IGF-IRα subunit Antibody, clone 1B1 is validated for use in Flow Cytometry, Immunocytochemistry, Western Blotting for the detection of IGF-IRα subunit.

Anti-IGF-IRα subunit Antibody, clone 1B1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书

Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: IGF1R, CD221, IGFIR, IGFR, JTK13 UniProt Number: P08069

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	FC, ICC, WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABS1301
Description	Anti-IGF-IRα subunit Antibody, clone 1B1
Alternate Names	Insulin-like growth factor 1 receptor CD221 IGF-I receptor Insulin-like growth factor I receptor Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain IGF-IRα subunit
Background Information	Insulin-like growth factor 1 receptor (EC:2.7.10.1; UniProt P08069; also known as CD221, IGF-I receptor, Insulin-like growth factor I receptor) is encoded by the IGF1R (also known as CD221, IGFIR, IGFR, JTK13) gene (Gene ID 3480) in human. The insulin-like growth factor 1 (IGF-1) receptor is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGF-1 receptor is initially produced as a precursor protein with a signal peptide sequence (aa 1-30). Post-translational cleavages produce one extracellular alpha (aa 31-736) chain and one transmembrane beta chain (aa 741 – 1367) linked together by a disulfide bond. Two sets of alpha-beta dimers then form the functional tetrameric receptor complex via a disulfide linkage between their alpha chain. Upon ligand binding, the alpha chains induce the tyrosine autophosphorylation of the beta chains, which in turn trigger cell type-specific downstream signaling cascade of events.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-IGF-IRα subunit Antibody, clone 1B1 is validated for use in Flow Cytometry, Immunocytochemistry, Western Blotting for the detection of IGF-IRα subunit.
Key Applications	Flow Cytometry Immunocytochemistry Western Blotting
Application Notes	Flow Cytometry Analysis: A representative lot detected IGF-I receptor on the surface of MCF-7 human breast cancer cells (Nakadate, Y., et al. (2014). Monoclon. Antib. Immunodiagn. Immunother. 33(2):126-128). Immunocytochemistry Analysis: A representative lot detected IGF-I receptor on the surface of MCF-7 human breast cancer cells (Nakadate, Y., et al. (2014). Monoclon. Antib. Immunodiagn. Immunother. 33(2):126-128). Western Blotting Analysis: A representative lot detected the extracellular alpha (aa 31-736) chain of IGF-1R in MCF-7 cell extracts (Nakadate, Y., et al. (2014). Monoclon. Antib. Immunodiagn. Immunother. 33(2):126-128).

Biological Information
Immunogen	Recombinant protein corresponding to the extracellular fragment of human IGF-IR precursor protein.
Epitope	IGF-IR extracellular alpha chain.
Clone	1B1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone 1B1 detected a band corresponding to the size of the alpha subunit of IGF-1R by immunoblotting analysis of recombinant protein and MCF-7 cell extracts (Nakadate, Y., et al. (2014). Monoclon. Antib. Immunodiagn. Immunother. 33(2):126-128).
Isotype	IgG2bκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000866
Gene Symbol	IGF1R CD221 IGFIR IGFR JTK13
Purification Method	Protein G Purified
UniProt Number	P08069
Molecular Weight	80.41 kDa calculated.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Flow Cytometry in MCF7 cells. Flow Cytometry Analysis: 0.1 µg of this antibody detected IGF-IRα subunit on MCF7 cells.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABS1301	04055977314991

Documentation

Anti-IGF-IRα subunit Antibody, clone 1B1 分析证书

标题	批号
Anti-IGF-IRα subunit, clone 1B1 -Q2642764	Q2642764

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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