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MABS490 Anti-Hexosaminidase subunit A Antibody, clone 13D12.1

Anti-Hexosaminidase subunit A Antibody, clone 13D12.1 is an antibody against Hexosaminidase subunit A for use in Western Blotting, Immunohistochemistry (Paraffin).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: HEXA UniProt Number: P06865
MABS490
100 μg  
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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS490
DescriptionAnti-Hexosaminidase subunit A Antibody, clone 13D12.1
Alternate Names
  • Beta-hexosaminidase subunit alpha
  • Hexosaminidase subunit A
  • Beta-N-acetylhexosaminidase subunit alpha
  • N-acetyl-beta-glucosaminidase subunit alpha
Background InformationBeta-hexosaminidase subunit alpha (EC 3.2.1.52; UniProt P06865; also known as Beta-N-acetylhexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase subunit alpha) is encoded by the HEXA (also known as TSD) gene (Gene ID 3073) in human. The enzyme β-hexosaminidase is composed of two polypeptide chains designated the α- and β- subunits. β-hexosaminidase interacts with its co-factor GM2 activator protein and catalyzes the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines. Mutations in any of the three genes coding for the two enzyme subunits and the co-factor protein are known causes of neurodegenerative autosomal recessive lysosomal storage diseases collectively known as GM2 gangliosidoses. Tay-Sachs disease (TSD) is linked to HEXA mutations, Sandhoff disease is linked to HEXB mutations, and AB-variant form is linked to GM2A mutations.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Hexosaminidase subunit A Antibody, clone 13D12.1 is an antibody against Hexosaminidase subunit A for use in Western Blotting, Immunohistochemistry (Paraffin).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected Hexosaminidase subunit A in 10 µg of human placenta tissue lysate.
Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected Hexosaminidase subunit A in human cerebral cortex and human small intestine tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the internal (C-terminal half) of human Hexosaminidase subunit A.
EpitopeInternal (C-terminal half)
Clone13D12.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityReactivity toward spliced isoform 2 has not been determined.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • HEXA
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~60 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Hexosaminidase subunit A in 10 µg of HepG2 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
MABS490 04055977297409