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ABS1038 Anti-FMO5 Antibody

Anti-FMO5 Antibody is an antibody against FMO5 for use in Western Blotting, Immunohistochemistry.

Anti-FMO5 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Toxicology & Drug Resistance Gene Symbol: FMO5 UniProt Number: P49326
ABS1038
100 µL  
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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IHCRbSerumPolyclonal Antibody
Description
Catalogue NumberABS1038
DescriptionAnti-FMO5 Antibody
Alternate Names
  • Dimethylaniline monooxygenase [N-oxide-forming] 5
  • Dimethylaniline oxidase 5
  • FMO 5
  • Hepatic flavin-containing monooxygenase 5
Background InformationDimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8; UniProt P49326; also known as Dimethylaniline oxidase 5, FMO 5, Hepatic flavin-containing monooxygenase 5) is encoded by the FMO5 gene (Gene ID 2330) in human. FMO5 belongs to the family of Flavin-containing monooxygenase (FMO) genes that encode ER membrane flavin-containing monooxygenases. Humans possess five functional FMO genes (FMO1 to FMO5). FMO 1, 2 and 3 catalyze NADPH-dependent oxygenation of a wide array of foreign chemicals, while little is known about FMO 4 expression, substrates or activity. FMO 5 is highly expressed in the liver in human and murine species. FMO 5 is known to catalyze the N-oxygenation of short-chain aliphatic primary amines (e.g., N-octylamine) and the S-oxygenation of S-methyl-esonarimod, an active metabolite of the anti-rheumatic esonarimod. FMO 5 is also demonstrated to catalyze a Baeyer-Villiger oxidation reaction. However, FMO 5 exhibits little or no activity towards classic FMO substrates, such as methimazole, trimethylamine, and benzydamine. Fmo5 gene disruption in mice is reported to result in slowed metabolic aging via pleiotropic effects.
References
Product Information
FormatSerum
PresentationRabbit polyclonal antibody serum with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-FMO5 Antibody is an antibody against FMO5 for use in Western Blotting, Immunohistochemistry.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesWestern Blotting Analysis: A 1:500 dilutioin from a representative lot detected FMO5 in 10 µg of MCF-7 membrane extract.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FMO5 in rat and human liver tissue sections.
Biological Information
ImmunogenLinear peptide corresponding to a sequence from the N-terminal region of human FMO5.
EpitopeN-terminal region.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityExpected to react with all three spliced isoforms of human FMO5 reported by UniProt (P49326).
Species Reactivity
  • Human
  • Rat
Species Reactivity NoteHuman, Rat. Predicted to react with Mouse, Bovine, Guinea Pig based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • FMO5
Purification MethodUnpurified
UniProt Number
Molecular Weight~55/52/32 kDa observed. 60.22 kDa (isoform 1), 32.48 kDa (isoform 2), 52.48 kDa (isoform 3) calculated. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human liver tissue microsomal extract.

Western Blotting Analysis: A 1:500 dilutioin of this antibody detected FMO5 in 10 µg of human liver tissue microsomal extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABS1038 04055977332278