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MABF2092-25UG Anti-CD44 Antibody, clone Hermes-1

Anti-CD44, clone Hermes-1, Cat. No. MABF2092, is a rat monoclonal antibody that detects human CD44 and has been tested for use in Flow Cytometry, Immunohistochemistry (Paraffin), and Immunoprecipitation.

Anti-CD44 Antibody, clone Hermes-1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: CD44, LHR, MDU2, MDU3, MIC4 UniProt Number: P16070
MABF2092-25UG
25 μg  
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFC, IH(P), IPRPurifiedMonoclonal Antibody
Description
Catalogue NumberMABF2092-25UG
DescriptionAnti-CD44 Antibody, clone Hermes-1
Alternate Names
  • CDw44
  • Epican
  • Extracellular matrix receptor III
  • ECMR-III
  • GP90
  • lymphocyte homing/adhesion receptor
  • HUTCH-I
  • Heparan sulfate proteoglycan
  • Hermes antigen
  • Hyaluronate receptor
  • Phagocytic glycoprotein 1
  • PGP-1
  • Phagocytic glycoprotein I
  • PGP-I
Background InformationCD44 antigen (UniProt: P16070; also known as CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I) is encoded by the CD44 (also known as LHR, MDU2, MDU3, MIC4) gene (Gene ID: 960) in human. CD44 is a single-pass type I membrane glycoprotein that is involved in cell-cell interactions, cell adhesion, and migration. It cell-cell and cell-matrix interactions are mediated through its affinity for hyaluronic acid (HA) and through other ligands. Adhesion with HA is considered to be important in cell migration, tumor growth, and progression. In cancer cells, it may play an important role in the formation of invadopodia. CD44 is synthesized with a signal peptide (aa 1-20), which is subsequently cleaved off to produce mature form. Its extracellular domain is localized to amino acids 21-649 and it has a short helical transmembrane domain (aa 650-670), and a cytoplasmic tail (aa 671-742). Nineteen different isoforms of CD44 are reported that are produced by alternative splicing.
References
Product Information
FormatPurified
PresentationPurified rat monoclonal antibody IgG2a in PBS without azide.
Applications
ApplicationAnti-CD44, clone Hermes-1, Cat. No. MABF2092, is a rat monoclonal antibody that detects human CD44 and has been tested for use in Flow Cytometry, Immunohistochemistry (Paraffin), and Immunoprecipitation.
Key Applications
  • Flow Cytometry
  • Immunohistochemistry (Paraffin)
  • Immunoprecipitation
Application NotesImmunohistochemistry Analysis: A representative lot detected CD44 in Immunohistochemistry applications (Jalkanen, S.T., et. al. (1986). Eur J Immunol. 16(10):1195-202).

Immunoprecipitation Analysis: A representative lot immunoprecipitated CD44 in Immunoprecipitation applications (Jalkanen, S.T., et. al. (1986). Eur J Immunol. 16(10):1195-202; Jalkanen, S., et. al. (1987). J Cell Biol. 105(2):983-90).

Flow Cytometry Analysis: A representative lot detected CD44 in Flow Cytometry applications (Jalkanen, S.T., et. al. (1986). Eur J Immunol. 16(10):1195-202).
Biological Information
ImmunogenHuman tonsil lymphocytes.
CloneHermes-1
ConcentrationPlease refer to lot specific datasheet.
HostRat
SpecificityClone hermes-1 is a rat monoclonal antibody that detects human CD44.
IsotypeIgG2aκ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CD44
  • LHR
  • MDU2
  • MDU3
  • MIC4
Purification MethodProtein G purified
UniProt Number
Molecular Weight81.54 kDa calculated for isoform 1.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human skin and human sweat gland tissues.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected CD44 in human skin and human sweat gland tissues.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.

Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
MABF2092-25UG 04054839460241