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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

OP93 Sigma-AldrichAnti-BRCA1 (Ab-2) Mouse mAb (MS13)

Anti-BRCA1 (Ab-2), mouse monoclonal, clone MS13, recognizes ~220 kDa BRCA1 in MCF-7 cells. It is validated for Western blotting, immunofluorescence, immunoprecipitation, and for paraffin sections.

Anti-BRCA1 (Ab-2) Mouse mAb (MS13) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Anti-Breast Cancer Susceptibility Protein

Recommended Products

概述

Replacement Information

重要规格表

Species Reactivity	Host	Antibody Type
H	M	Monoclonal Antibody

Products

产品目录编号	包装	数量 / 包装
OP93-100UGCN	塑胶安瓿;塑胶针药瓶	100 μg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Recognizes the ~220 kDa BRCA1 protein in MCF-7 cells. Does not react with blood group antigens or growth factor receptors such as EGFR. Sold under license of U.S. Patent 5,753,441 and 6,162,897.
Catalogue Number	OP93
Brand Family	Calbiochem®
Synonyms	Anti-Breast Cancer Susceptibility Protein

References
References	Scully, R., et al. 1996. Science 272, 123. Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717. Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711. Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113. Merajver, S.D., et al. 1995. Clin. Can. Res. 1, 539. Merajver, S.D., et al. 1995. Nat. Genet. 9, 439. Struewing, J.P., et al. 1995. Nat. Genet. 11, 198. Thompson, M.E., et al. 1995. Nat. Genet. 9, 444. Futreal, P.A., et al. 1994. Science 266, 120. Miki, Y., et al. 1994. Science 266, 66.

References

Scully, R., et al. 1996. Science 272, 123.
Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717.
Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711.
Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113.
Merajver, S.D., et al. 1995. Clin. Can. Res. 1, 539.
Merajver, S.D., et al. 1995. Nat. Genet. 9, 439.
Struewing, J.P., et al. 1995. Nat. Genet. 11, 198.
Thompson, M.E., et al. 1995. Nat. Genet. 9, 444.
Futreal, P.A., et al. 1994. Science 266, 120.
Miki, Y., et al. 1994. Science 266, 66.

Product Information
Declaration	Sold under license of U.S. Patents 5,753,441 and 6,162,897.
Form	Liquid
Formulation	In 0.05 M sodium phosphate buffer, 0.2% gelatin.
Positive control	MCF7 cells
Preservative	≤0.1% sodium azide
Quality Level	MQ100

Applications
Application References	Immunoblotting, Immunoprecipitation, Immunofluorescence, Paraffin Sections Scully, R., et al. 1996. Science 272, 123.
Key Applications	Immunoblotting (Western Blotting) Immunofluorescence Immunoprecipitation Paraffin Sections
Application Notes	Immunoblotting (2 µg/ml, chemiluminescence; see application references) Immunofluorescence (see application references) Immunoprecipitation (see application references) Paraffin Sections (see application references)
Application Comments	Antibody should be titrated for optimal results in individual systems.

Biological Information
Immunogen	recombinant, human BRCA1
Immunogen	Human
Epitope	within amino acids 1-304
Clone	MS13
Host	Mouse
Isotype	IgG₁
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Yes

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
OP93-100UGCN	04055977209693

Documentation

Anti-BRCA1 (Ab-2) Mouse mAb (MS13) MSDS

职位
物料安全数据表 (MSDS)

Anti-BRCA1 (Ab-2) Mouse mAb (MS13) 分析证书

标题	批号
OP93	输入批号

参考

参考信息概述
Scully, R., et al. 1996. Science 272, 123. Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717. Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711. Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113. Merajver, S.D., et al. 1995. Clin. Can. Res. 1, 539. Merajver, S.D., et al. 1995. Nat. Genet. 9, 439. Struewing, J.P., et al. 1995. Nat. Genet. 11, 198. Thompson, M.E., et al. 1995. Nat. Genet. 9, 444. Futreal, P.A., et al. 1994. Science 266, 120. Miki, Y., et al. 1994. Science 266, 66.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-October-2007 RFH
Synonyms	Anti-Breast Cancer Susceptibility Protein
Application	Immunoblotting (2 µg/ml, chemiluminescence; see application references) Immunofluorescence (see application references) Immunoprecipitation (see application references) Paraffin Sections (see application references)
Description	Purified mouse monoclonal antibody generated by immunizing mice with the specified iummunogen and fusing splenocytes with NS1 mouse myeloma cells. Recognizes the ~220 kDa BRCA1 protein.
Background	Inactivation of the BRCA1 gene, located at 17q21, is responsible for some forms of familial breast and ovarian cancer and sporadic ovarian cancer. BRCA1 encodes a protein of 1863 amino acids with an amino-terminal domain that exhibits similarity to the zinc-ring domain found in several regulatory and transcription factors. Mutations that disrupt this domain are some of the most frequently occurring ones linked to breast and ovarian cancer. Inhibition of BRCA1 expression leads to accelerated growth of mammary cells in vitro while loss of expression is observed during progression from benign disease to metastatic breast cancer suggesting that BRCA1 serves as a negative growth regulator. The ~220 kDa BRCA1 protein is expressed predominantly in the nucleus and appears to undergo cell cycle regulation with mRNA expression induced prior to DNA synthesis.
Host	Mouse
Immunogen species	Human
Immunogen	recombinant, human BRCA1
Epitope	within amino acids 1-304
Clone	MS13
Isotype	IgG₁
Species	human
Positive control	MCF7 cells
Form	Liquid
Formulation	In 0.05 M sodium phosphate buffer, 0.2% gelatin.
Concentration Label	Please refer to vial label for lot-specific concentration
Preservative	≤0.1% sodium azide
Comments	Antibody should be titrated for optimal results in individual systems.
Storage	+2°C to +8°C
Do Not Freeze	Yes
Toxicity	Standard Handling
References	Scully, R., et al. 1996. Science 272, 123. Gudas, J.M., et al. 1996. Cell Growth Differ. 7, 717. Vaughn, J.P., et al. 1996. Cell Growth Differ. 7, 711. Goldgar, D.E. and Reilly, P.R. 1995. Nat. Genet. 11, 113. Merajver, S.D., et al. 1995. Clin. Can. Res. 1, 539. Merajver, S.D., et al. 1995. Nat. Genet. 9, 439. Struewing, J.P., et al. 1995. Nat. Genet. 11, 198. Thompson, M.E., et al. 1995. Nat. Genet. 9, 444. Futreal, P.A., et al. 1994. Science 266, 120. Miki, Y., et al. 1994. Science 266, 66.
Application references	Immunoblotting, Immunoprecipitation, Immunofluorescence, Paraffin Sections Scully, R., et al. 1996. Science 272, 123.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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