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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN466 Sigma-AldrichAnti-Ankyrin-G Antibody, clone N106/36

Anti-Ankyrin-G Antibody, clone N106/36 is a highly specific mouse monoclonal antibody & that targets Ankyrin & has been tested in IHC.

Anti-Ankyrin-G Antibody, clone N106/36 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: ANK3 UniProt Number: Q12955

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R	IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN466
Description	Anti-Ankyrin-G Antibody, clone N106/36
Alternate Names	Ankyrin-3 ANK-3 Ankyrin-G
Background Information	Ankyrins are a family of spectrin-binding proteins that couple the spectrin/actin cytoskeletal network to the cytoplasmic domains of integral membrane proteins which include channels such as the anion exchanger, voltage-dependent sodium channel, and the Na/K ATPase, as well as neuronal cell adhesion molecules related to L1. In the nervous system, three different ankyrins are known to exist; ankyrinB, ankyrinG, and ankyrinR. All three ankyrins contain an N-terminal membrane binding domain, an internal domain capable of binding spectrin, and a C-terminal regulatory domain which is the target of alternative splicing. AnkyrinB, the predominant neuronal ankyrin includes two isoforms of ~220 kDa and ~440 kDa. The ~220 kDa alternatively spliced isoform is the major form present in the adult brain, while the ~440 kDa form is preferentially expressed in the developing neonatal brain. Three forms of ankyrinG (~190 kDa, ~270 kDa, ~480 kDa) are localized in axonal initial segments and the nodes of Ranvier of myelinated axons where fluxes of action potential occur and ion channels are enriched. Ankyrins comprise ~0.5%-1% of the total membrane protein in the adult vertebrate brain.

References

Product Information
Format	Purified
Control	Rat hippocampus tissue
Presentation	Purified mouse monoclonal IgG2aκ in 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Ankyrin-G Antibody, clone N106/36 is a highly specific mouse monoclonal antibody & that targets Ankyrin & has been tested in IHC.
Key Applications	Immunohistochemistry
Application Notes	Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Ankyrin-G in rat cerebral cortex tissue. Immunohistochemistry Analysis: A representative lot detected Ankyrin-G in rat optic nerve tissue. Immunofluorescence Analysis: A representative lot detected Ankyrin-G in adult rat cortex tissue. Immunofluorescence Analysis: A representative lot from an independent laboratory detected Ankyrin-G in a rat model of TLE mEC layer II neurons (Hargus, N. J., et al. (2011). Neurobiol Dis. 41(2):361-376.)

Biological Information
Immunogen	Recombinant protein corresponding to human Ankyrin-G.
Clone	N106/36
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Rat
Species Reactivity Note	Demonstrated to react with Rat. Other homologies: Human (92% sequence homology), and Mouse (87% sequence homology).
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_066267
Gene Symbol	ANK3
Purification Method	Protein G Purified
UniProt Number	Q12955
Molecular Weight	480 kDa calculated

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Immunohistochemistry in rat hippocampus tissue. Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Ankyrin-G in rat hippocampus tissue.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN466	04053252830587

Documentation

Anti-Ankyrin-G Antibody, clone N106/36 MSDS

职位
物料安全数据表 (MSDS)

Anti-Ankyrin-G Antibody, clone N106/36 分析证书

标题	批号
Anti-Ankyrin-G, clone N106/36 - 2952322	2952322
Anti-Ankyrin-G, clone N106/36 - 3213939	3213939
Anti-Ankyrin-G, clone N106/36 - 3307318	3307318
Anti-Ankyrin-G, clone N106/36 - 3324989	3324989
Anti-Ankyrin-G, clone N106/36 - 3462114	3462114
Anti-Ankyrin-G, clone N106/36 - 3503449	3503449
Anti-Ankyrin-G, clone N106/36 - 3681275	3681275
Anti-Ankyrin-G, clone N106/36 - 3743894	3743894
Anti-Ankyrin-G, clone N106/36 - 3868387	3868387
Anti-Ankyrin-G, clone N106/36 - 3879505	3879505

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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