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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

OP80 Sigma-AldrichAnti-APC (Ab-7) Mouse mAb (CC-1)

Anti-APC (Ab-7), mouse monoclonal, clone CC-1, recognizes APC in oligodendrocytes and astrocytes. It is validated for ICC, IF, free-floating Sections, and paraffin and frozen sections.

Anti-APC (Ab-7) Mouse mAb (CC-1) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: Anti-Adenomatus Polyposis Coli

Recommended Products

概述

Replacement Information

重要规格表

Species Reactivity	Host	Antibody Type
H, M, R	M	Monoclonal Antibody

Products

产品目录编号	包装	数量 / 包装
OP80-100UGCN	塑胶安瓿;塑胶针药瓶	100 μg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Recognizes APC in oligodendrocytes and astrocytes. Antibody Target Gene Symbol: APC Target Synonym: AI047805, Apc7, AU020952, AW124434, BTPS2, DP2, DP2.5, DP3, Familial adenomatous polyposis, FAP, GS, Min, RATAPC Entrez Gene Name: adenomatous polyposis coli Hu Entrez ID: 324 (Related Antibodies: ST1150, OP62, OP47L, OP44) Mu Entrez ID: 11789 Rat Entrez ID: 24205
Catalogue Number	OP80
Brand Family	Calbiochem®
Synonyms	Anti-Adenomatus Polyposis Coli

References
References	Bhat, R.V., et al. 1996. Glia 17, 169. Bhat, R.V., et al. 1994. Neuroscience Proceedings. Smith, K.J., et al. 1994. Cancer Res. 54, 3672. Smith, K.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2846. Su, L.-K., et al. 1993. Cancer Res. 53, 2728. Su, L.-K., et al. 1993. Science 262, 1734. Groden, J., et al. 1991. Cell 66, 589. Kinzler, K.W., et al. 1991. Science 251, 1366.

References

Bhat, R.V., et al. 1996. Glia 17, 169.
Bhat, R.V., et al. 1994. Neuroscience Proceedings.
Smith, K.J., et al. 1994. Cancer Res. 54, 3672.
Smith, K.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2846.
Su, L.-K., et al. 1993. Cancer Res. 53, 2728.
Su, L.-K., et al. 1993. Science 262, 1734.
Groden, J., et al. 1991. Cell 66, 589.
Kinzler, K.W., et al. 1991. Science 251, 1366.

Product Information
Form	Liquid
Formulation	In 50 mM sodium phosphate buffer, 0.2% gelatin.
Negative control	MOPC 21 cells
Positive control	Purkinje cells or cerebellum tissue
Preservative	≤0.1% sodium azide
Quality Level	MQ100

Applications
Application References	Immunocytochemistry McTigue, D.M., et al. 2001. J. Neurosci. 21, 3392. Free Floating Sections Ding, H., et al. 2003. Cancer Res. 63, 1106.
Key Applications	Free-floating Sections Frozen Sections Immunocytochemistry Immunofluorescence Paraffin Sections
Application Notes	Frozen Sections (5 µg/ml) Immunofluorescence (5 µg/ml) Paraffin Sections (5 µg/ml, heat pre-treament required) Immunocytochemistry (see application references) Free Floating Sections (see application references)
Application Comments	Well suited for IHC and IF studies of oligodendrocytes and optic nerves due to the antibody's staining of the cell body as opposed to the myelinated processes. Both frozen sections and formalin-fixed, paraffin-embedded brain sections can be used. Antibody should be titrated for optimal results in individual systems.

Biological Information
Immunogen	a recombinant protein consisting of amino acids 1-226 of APC
Clone	CC-1
Host	Mouse
Isotype	IgG_2b
Species Reactivity	Human Mouse Rat
Antibody Type	Monoclonal Antibody
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Yes

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
OP80-100UGCN	04055977209662

Documentation

Anti-APC (Ab-7) Mouse mAb (CC-1) 分析证书

标题	批号
OP80	输入批号

参考

参考信息概述
Bhat, R.V., et al. 1996. Glia 17, 169. Bhat, R.V., et al. 1994. Neuroscience Proceedings. Smith, K.J., et al. 1994. Cancer Res. 54, 3672. Smith, K.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2846. Su, L.-K., et al. 1993. Cancer Res. 53, 2728. Su, L.-K., et al. 1993. Science 262, 1734. Groden, J., et al. 1991. Cell 66, 589. Kinzler, K.W., et al. 1991. Science 251, 1366.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-November-2007 JSW
Synonyms	Anti-Adenomatus Polyposis Coli
Application	Frozen Sections (5 µg/ml) Immunofluorescence (5 µg/ml) Paraffin Sections (5 µg/ml, heat pre-treament required) Immunocytochemistry (see application references) Free Floating Sections (see application references)
Description	Purified mouse monoclonal antibody generated by immunizing CB6 F1 mice with the specified immunogen and fusing splonocytes with SP2/O mouse myeloma cells. Recognizes the ~312 kDa APC protein.
Background	Germ line mutations in the APC gene are responsible for familial adenomatous polyposis and somatic mutations contribute to sporadic colorectal cancer. The 312 kDa APC protein is expressed in all tissues and localized to the cytoskeletal architecture in an insoluble complex with β-catenin. The APC (Ab-7) mouse monoclonal antibody clone CC-1 decorates oligodendrocyte cell bodies, purkinje cells, astrocytes, and optic nerve cell bodies of formalin-fixed, paraffin-embedded, or fresh frozen sections from human, mouse, and rat brain. Dectection of APC (Ab-7) can be perfomed using immunofluorescence or immunohistochemistry techniques.
Host	Mouse
Immunogen	a recombinant protein consisting of amino acids 1-226 of APC
Clone	CC-1
Isotype	IgG_2b
Species	human, mouse, rat
Positive control	Purkinje cells or cerebellum tissue
Negative control	MOPC 21 cells
Form	Liquid
Formulation	In 50 mM sodium phosphate buffer, 0.2% gelatin.
Concentration Label	Please refer to vial label for lot-specific concentration
Preservative	≤0.1% sodium azide
Comments	Well suited for IHC and IF studies of oligodendrocytes and optic nerves due to the antibody's staining of the cell body as opposed to the myelinated processes. Both frozen sections and formalin-fixed, paraffin-embedded brain sections can be used. Antibody should be titrated for optimal results in individual systems.
Storage	+2°C to +8°C
Do Not Freeze	Yes
Toxicity	Standard Handling
References	Bhat, R.V., et al. 1996. Glia 17, 169. Bhat, R.V., et al. 1994. Neuroscience Proceedings. Smith, K.J., et al. 1994. Cancer Res. 54, 3672. Smith, K.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2846. Su, L.-K., et al. 1993. Cancer Res. 53, 2728. Su, L.-K., et al. 1993. Science 262, 1734. Groden, J., et al. 1991. Cell 66, 589. Kinzler, K.W., et al. 1991. Science 251, 1366.
Application references	Immunocytochemistry McTigue, D.M., et al. 2001. J. Neurosci. 21, 3392. Free Floating Sections Ding, H., et al. 2003. Cancer Res. 63, 1106.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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