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05-23-0101 Sigma-AldrichAngiotensin II, Human - CAS 4474-91-3 - Calbiochem

Plays an important role in the regulation of blood pressure.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: DRVYIHPF

Primary Target: adenylate cyclase activity

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
4474-91-3	C₅₀H₇₁N₁₃O₁₂

Products

产品目录编号	包装	数量 / 包装
05-23-0101-1MGCN	塑胶安瓿;塑胶针药瓶	1 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹
05-23-0101-25MGCN	玻璃瓶	25 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹
05-23-0101-5MGCN	塑胶安瓿;塑胶针药瓶	5 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca²⁺ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K⁺ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125^FAKand a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60^c-src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.
Catalogue Number	05-23-0101
Brand Family	Calbiochem®
Synonyms	DRVYIHPF

References
References	Zhu, M., et al. 2000. J. Neurophysiol. 84, 2494. Natarajan, R., et al. 1999. Hypertension 33, 378. Mazzolai, L., et al. 1998. Hypertension 31, 1324. Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440. Ishida, M., et al. 1995. Circ. Res. 77, 1053. Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

Product Information
CAS number	4474-91-3
ATP Competitive	N
Form	White to off-white solid
Hill Formula	C₅₀H₇₁N₁₃O₁₂
Chemical formula	C₅₀H₇₁N₁₃O₁₂
Hygroscopic	Hygroscopic
Reversible	N
Sold on the basis of peptide content	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	adenylate cyclase activity
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Content	Y
Peptide Sequence	H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	BW2165000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
05-23-0101-1MGCN	04055977206906
05-23-0101-25MGCN	04055977206913
05-23-0101-5MGCN	04055977206920

Documentation

Angiotensin II, Human - CAS 4474-91-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Angiotensin II, Human - CAS 4474-91-3 - Calbiochem 分析证书

标题	批号
05-23-0101	输入批号

参考

参考信息概述
Zhu, M., et al. 2000. J. Neurophysiol. 84, 2494. Natarajan, R., et al. 1999. Hypertension 33, 378. Mazzolai, L., et al. 1998. Hypertension 31, 1324. Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440. Ishida, M., et al. 1995. Circ. Res. 77, 1053. Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-May-2008 JSW
Synonyms	DRVYIHPF
Description	Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca²⁺ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125^FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.
Form	White to off-white solid
CAS number	4474-91-3
RTECS	BW2165000
Chemical formula	C₅₀H₇₁N₁₃O₁₂
Peptide Sequence	H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Purity	≥98% by HPLC
Solubility	5% acetic acid (1 mg/ml) or H₂O (1 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Toxicity	Standard Handling
Merck USA index	14 651
References	Zhu, M., et al. 2000. J. Neurophysiol. 84, 2494. Natarajan, R., et al. 1999. Hypertension 33, 378. Mazzolai, L., et al. 1998. Hypertension 31, 1324. Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440. Ishida, M., et al. 1995. Circ. Res. 77, 1053. Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Adenylate Cyclase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Neuropeptides

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