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172060 Andrographolide - CAS 5508-58-7 - Calbiochem

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties.

Andrographolide - CAS 5508-58-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Andro

Primary Target: NF-κB and AP-1 activation
172060
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概述

重要规格表

CAS #Empirical Formula
5508-58-7C₂₀H₃₀O₅

Products

产品目录编号包装 数量 / 包装
172060-50MGCN 塑胶安瓿;塑胶针药瓶 50 mg
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Description
OverviewA bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
Catalogue Number172060
Brand Family Calbiochem®
SynonymsAndro
References
ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
Yu, B.C., et al. 2003. Planta Med. 69, 1075.
Product Information
CAS number5508-58-7
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₀H₃₀O₅
Chemical formulaC₂₀H₃₀O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetNF-κB and AP-1 activation
Primary Target IC<sub>50</sub>≤ 15 µM against NF-κB and AP-1 activation
Purity≥95% by TLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSLU3490750
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
产品目录编号 GTIN
172060-50MGCN 04055977222883