124036 Sigma-AldrichAkt Inhibitor XVIII, SC66 - Calbiochem
The Akt Inhibitor XVIII, SC66 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Akt Inhibitor XVIII, SC66 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<Akt Inhibitor XVIII, SC66 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: (2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone
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概述
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重要规格表
| Empirical Formula |
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| C₁₈H₁₆N₂O |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
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| 124036-25MGCN | 玻璃瓶 | 25 mg |
| Description | |
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| Overview | A cell-permeable pyridine compound that selectively targets Akt, but not PLCδ, PH domain, preventing Akt membrane localization/activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 (Cat. Nos. 124017 & 124018) competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4 µM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30 mg/kg), Synergizes with LY294002 (Cat. Nos. 440202 & 440204) in cell death induction in HeLa and HS-Sultan cultures in vitro. |
| Catalogue Number | 124036 |
| Brand Family | Calbiochem® |
| Synonyms | (2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone |
| References | |
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| References | Jo, H., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 6486. |
| Product Information | |
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| Form | Pale yellow solid |
| Hill Formula | C₁₈H₁₆N₂O |
| Chemical formula | C₁₈H₁₆N₂O |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 124036-25MGCN | 04055977205824 |
Documentation
Akt Inhibitor XVIII, SC66 - Calbiochem MSDS
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Akt Inhibitor XVIII, SC66 - Calbiochem 分析证书
| 标题 | 批号 |
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| 124036 |
参考
| 参考信息概述 |
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| Jo, H., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 6486. |
小册子
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| New Products: Volume 3, 2012 |