114825 Sigma-AldrichAdapalene - CAS 106685-40-9 - Calbiochem
A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα.
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同义词: CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 106685-40-9 | C₂₈H₂₈O₃ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
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| 114825-25MGCN | 25 mg |
| Description | |
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| Overview | A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo. |
| Catalogue Number | 114825 |
| Brand Family | Calbiochem® |
| Synonyms | CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271 |
| Product Information | |
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| CAS number | 106685-40-9 |
| Form | White solid |
| Hill Formula | C₂₈H₂₈O₃ |
| Chemical formula | C₂₈H₂₈O₃ |
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| Quality Level | MQ100 |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 114825-25MGCN | 04055977208122 |
Documentation
Adapalene - CAS 106685-40-9 - Calbiochem MSDS
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Adapalene - CAS 106685-40-9 - Calbiochem 分析证书
| 标题 | 批号 |
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| 114825 |
参考
| 参考信息概述 |
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| Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421. Ocker, M., et al. 2003. Int. J. Cancer 107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96. |
小册子
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技术信息
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用户指南
产品插页
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| Spectroquant®Prove Quick Guide - Chinese Simplified |