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GF164 ANG-1 Protein, Human Recombinant

The Ang-1 protein & Ang-2 protein are secreted ligands which bind with similar affinity to Tie2, a receptor tyrosine kinase with immunoglobulin & epidermal growth factor homology domains expressed on endothelial & early hematopoietic cells.

ANG-1 Protein, Human Recombinant MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: Q15389
GF164
20 µg  
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

SourcePurity
Hela CellsProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
Description
Catalogue NumberGF164
DescriptionANG-1 Protein, Human Recombinant
Alternate Names
  • ANG1
  • Angiopoietin1
  • Hepatic fibrinogen/angiopoietin-related protein
  • PPARG angiopoietin related protein
  • angiopoietin-like 4
  • angiopoietin-like 4 protein
  • angiopoietin-related protein 4
Background InformationAngiopoietin1 (Ang1) and Angiopoietin2 (Ang2) are two closely related secreted ligands which bind with similar affinity to Tie2,
a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Tie2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 (Ang-2), a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules, Ang-1 enhances endothelial cell survival and capillary morphogenesis, and lessens capillary permeability. As such, Ang-1 has a potential to become an effective therapeutic agent for treating various endothelium disorders, including several severe human pulmonary diseases. Recombinant human ANG-1, derived from HeLa cells, is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein.
References
Product Information
PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
ApplicationThe Ang-1 protein & Ang-2 protein are secreted ligands which bind with similar affinity to Tie2, a receptor tyrosine kinase with immunoglobulin & epidermal growth factor homology domains expressed on endothelial & early hematopoietic cells.
Biological Information
PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
SourceHela Cells
Cross ReactivityNone
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceBioactivity assay: Determined by its ability to induce adhesion of human umbilical vein endothelial cells (HUVEC).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
Packaging Information
Material Size20 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
GF164 04053252691218

Documentation

ANG-1 Protein, Human Recombinant MSDS

职位

物料安全数据表 (MSDS) 

ANG-1 Protein, Human Recombinant 分析证书

标题批号
Recombinant Human -2556024 2556024
Recombinant Human -2804758 2804758
Recombinant Human ANG-1 - 2074788 2074788
Recombinant Human ANG-1 - 3481381 3481381
Recombinant Human ANG-1 - 3800036 3800036
Recombinant Human ANG-1 - 4029331 4029331
Recombinant Human ANG-1 - Q2007170 Q2007170
Recombinant Human ANG-1 Recombinant Protein 2893646
Recombinant Human ANG-1 Recombinant Protein 3121775

小册子

标题
New Products: Volume 3, 2012