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118415 ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem

ADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄

Primary Target: PARG
118415
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概述

重要规格表

Empirical Formula
C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O

Products

产品目录编号包装 数量 / 包装
118415-1SETCN 玻璃瓶 1 set
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118415-60UGCN 塑胶安瓿;塑胶针药瓶 60 μg
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Description
OverviewAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Note: 1 set = 5 x 60 µg.
Note: 1 set = 5 x 60 µg
Catalogue Number118415
Brand Family Calbiochem®
SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
References
ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).
Biological Information
Primary TargetPARG
Primary Target IC<sub>50</sub>120 nM against poly(ADP-ribose) glycohydrolase (PARG)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
产品目录编号 GTIN
118415-1SETCN 04055977224009
118415-60UGCN 07790788047887