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345868 Sigma-Aldrich[6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem

An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone

Primary Target: Activator Protein-1 (AP-1)

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
23513-14-6	C₁₇H₂₆O₄

Products

产品目录编号	包装	数量 / 包装
345868-5MGCN	塑胶安瓿;塑胶针药瓶	5 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca²⁺-ATPase activity in cardiac sarcoplasmic reticulum (EC₅₀ = 4 µM) and increases Ca²⁺ uptake.
Catalogue Number	345868
Brand Family	Calbiochem®
Synonyms	1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone

References
References	Bode, A.M., et al. 2001. Cancer Res. 61, 850. Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227. Park, K.K.,et al. 1998. Cancer Lett. 129, 139. Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.

Product Information
CAS number	23513-14-6
ATP Competitive	N
Form	Pale yellow oil
Hill Formula	C₁₇H₂₆O₄
Chemical formula	C₁₇H₂₆O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Activator Protein-1 (AP-1)
Primary Target IC<sub>50</sub>	EC50 = 4 µM increasing the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	HE0757000

Safety Information
R Phrase	R: 20/21/22-36/37/38 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
345868-5MGCN	04055977214437

Documentation

[6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

[6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem 分析证书

标题	批号
345868	输入批号

参考

参考信息概述
Bode, A.M., et al. 2001. Cancer Res. 61, 850. Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227. Park, K.K.,et al. 1998. Cancer Lett. 129, 139. Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-June-2008 RFH
Synonyms	1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone
Description	Phytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca²⁺-ATPase activity of the sarcoplasmic reticulum (EC₅₀ = 4 µM).
Form	Pale yellow oil
Intert gas (Yes/No)	Packaged under inert gas
CAS number	23513-14-6
RTECS	HE0757000
Chemical formula	C₁₇H₂₆O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.
Toxicity	Harmful
References	Bode, A.M., et al. 2001. Cancer Res. 61, 850. Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227. Park, K.K.,et al. 1998. Cancer Lett. 129, 139. Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Inducers > Apoptosis Inducers

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