Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

410957 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: IBMX

Primary Target: cAMP and cGMP phosphodiesterases
410957
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
28822-58-4C₁₀H₁₄N₄O₂

Products

产品目录编号包装 数量 / 包装
410957-1GMCN 塑胶安瓿;塑胶针药瓶 1 gm
410957-250MGCN 塑胶安瓿;塑胶针药瓶 250 mg
Description
OverviewA cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.
Catalogue Number410957
Brand Family Calbiochem®
SynonymsIBMX
References
ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.
Product Information
CAS number28822-58-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₄N₄O₂
Chemical formulaC₁₀H₁₄N₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Application3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).
Biological Information
Primary TargetcAMP and cGMP phosphodiesterases
Primary Target IC<sub>50</sub>2-50 µM against cAMP and cGMP phosphodiesterases
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSZD8500000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
410957-1GMCN 04055977211139
410957-250MGCN 04055977211146

Documentation

3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem 分析证书

标题批号
410957

参考

参考信息概述
Hube, F., et al. 1999. Horm. Metab. Res. 31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

小册子

标题
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2013 JSW
SynonymsIBMX
DescriptionA non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.
FormWhite solid
CAS number28822-58-4
RTECSZD8500000
Chemical formulaC₁₀H₁₄N₄O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM), Ethanol (10 mg/ml), or Methanol (50 mg/ml). Heating may be required to achieve complete solubilization.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
Toxicity Standard Handling
ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.