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288104 2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem

Cell-permeable, non-competitive adenylate cyclase inhibitor (IC₅₀ = 3 µM), that binds to the adenosine P1 binding site.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 2ʹ,5ʹ-dd-Ado

Primary Target: adenylate cyclase
288104
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
6698-26-6C₁₀H₁₃N₅O₂

Products

产品目录编号包装 数量 / 包装
288104-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewCell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of β-adrenergic agents.
Catalogue Number288104
Brand Family Calbiochem®
Synonyms2ʹ,5ʹ-dd-Ado
References
ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.
Product Information
CAS number6698-26-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₃N₅O₂
Chemical formulaC₁₀H₁₃N₅O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetadenylate cyclase
Primary Target IC<sub>50</sub>3 µM against adenylate cyclase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
288104-1MGCN 04055977197914

Documentation

2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem 分析证书

标题批号
288104

参考

参考信息概述
Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.

小册子

标题
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-June-2008 RFH
Synonyms2ʹ,5ʹ-dd-Ado
DescriptionMembrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC50 = 3 µM for detergent solubilized rat brain membranes; IC50 = 45 µM for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC50 = 540 µM) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of β-adrenergic agents.
FormWhite solid
CAS number6698-26-6
Chemical formulaC₁₀H₁₃N₅O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.