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100068 17-AAG - CAS 75747-14-7 - Calbiochem

A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus.

17-AAG - CAS 75747-14-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin

Primary Target: Hsp90
100068
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
75747-14-7C₃₁H₄₃N₃O₈

Products

产品目录编号包装 数量 / 包装
100068-500UGCN 塑胶安瓿;塑胶针药瓶 500 μg
Description
OverviewA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53 (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression.
Catalogue Number100068
Brand Family Calbiochem®
SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
References
ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
Product Information
CAS number75747-14-7
ATP CompetitiveN
FormPurple solid
Hill FormulaC₃₁H₄₃N₃O₈
Chemical formulaC₃₁H₄₃N₃O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHsp90
Primary Target IC<sub>50</sub>EC50 = 7.2 µM for Hsp90
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
100068-500UGCN 04055977226881

Documentation

17-AAG - CAS 75747-14-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

17-AAG - CAS 75747-14-7 - Calbiochem 分析证书

标题批号
100068

参考

参考信息概述
Basso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

数据表

标题
Data Sheet 1.00068.0500

用户指南

标题
Pack insert Bolton Broth Selective Supplement 1.00079.0010
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2007 RFH
SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
DescriptionA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Reported to induce apoptosis and exhibit anti-tumor properties (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53, (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt. Hence, inhibits the Ras/Raf/MEK and PI3-Kinase signaling pathways. Shown to sensitize cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380), and down-regulates vascular endothelial factor expression.
FormPurple solid
Intert gas (Yes/No) Packaged under inert gas
CAS number75747-14-7
Chemical formulaC₃₁H₄₃N₃O₈
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.