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487910 (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: SNAP

487910
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
79032-48-7C₇H₁₂N₂O₄S

Products

产品目录编号包装 数量 / 包装
487910-1SETCN 玻璃瓶 1 set
487910-20MGCN 塑胶安瓿;塑胶针药瓶 20 mg
Description
OverviewNitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
Catalogue Number487910
Brand Family Calbiochem®
SynonymsSNAP
References
ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
Product Information
CAS number79032-48-7
ATP CompetitiveN
FormPale green solid
Hill FormulaC₇H₁₂N₂O₄S
Chemical formulaC₇H₁₂N₂O₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNitric oxide donor
Primary Target IC<sub>50</sub>EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
487910-1SETCN 04055977200324
487910-20MGCN 04055977200331

Documentation

(±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

(±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem 分析证书

标题批号
487910

参考

参考信息概述
Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题
  • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
    		•
    数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision25-October-2016 JSW
    SynonymsSNAP
    DescriptionNitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
    FormPale green solid
    CAS number79032-48-7
    Chemical formulaC₇H₁₂N₂O₄S
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (25 mg/ml), Ethanol (25 mg/ml), or Methanol
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
    Toxicity Irritant
    ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
    Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
    Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
    Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
    Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
    Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
    Citation
  • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
    		•