Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

565740 α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem

565740
Purchase on Sigma-Aldrich

概述

重要规格表

CAS #Empirical Formula
497259-23-1C₂₇H₃₀F₃N₃O₃

Products

产品目录编号包装 数量 / 包装
565740-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewA cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity.
Catalogue Number565740
Brand Family Calbiochem®
Synonyms(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
References
ReferencesKozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.
Product Information
CAS number497259-23-1
ATP CompetitiveN
FormOrange solid
Hill FormulaC₂₇H₃₀F₃N₃O₃
Chemical formulaC₂₇H₃₀F₃N₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPKC
Primary Target K<sub>i</sub>11.9 nM for activating PKCα
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
产品目录编号 GTIN
565740-1MGCN 04055977267648