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554720 trans-Retinoic Acid - CAS 302-79-4 - Calbiochem

Potent modulator of growth and differentiation. Inhibits melanocyte adhesion, motility, and growth.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Tretinoin, ATRA, Vitamin A Acid

554720
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
302-79-4C₂₀H₂₈O₂

Products

Catalogue NumberPackaging Qty/Pack
554720-500MGCN Glass bottle 500 mg
Description
OverviewPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells. PROTECT FROM AIR.
Catalogue Number554720
Brand Family Calbiochem®
SynonymsTretinoin, ATRA, Vitamin A Acid
References
ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
Labbaye, C., et al. 1993. Blood 81, 475.
Sakashita, A., et al. 1993. Blood 81, 1009.
Situ, R., et al. 1993. Dermatology 186, 38.
Tini, M., et al. 1993. Genes Develop. 7, 295.
Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
Sharpe, C.R. 1991. Neuron 7, 239.
Thaller, C. and Eichele, G. 1990. Nature 345, 815.
Product Information
CAS number302-79-4
FormYellow solid
Hill FormulaC₂₀H₂₈O₂
Chemical formulaC₂₀H₂₈O₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by assay
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSVH6475000
Safety Information
R PhraseR: 22-36/37/38-63

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
Possible risk of harm to the unborn child.
S PhraseS: 22-26-36

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
554720-500MGCN 04061838431332

Documentation

trans-Retinoic Acid - CAS 302-79-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

trans-Retinoic Acid - CAS 302-79-4 - Calbiochem Certificates of Analysis

TitleLot Number
554720

References

Reference overview
Tosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
Labbaye, C., et al. 1993. Blood 81, 475.
Sakashita, A., et al. 1993. Blood 81, 1009.
Situ, R., et al. 1993. Dermatology 186, 38.
Tini, M., et al. 1993. Genes Develop. 7, 295.
Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
Sharpe, C.R. 1991. Neuron 7, 239.
Thaller, C. and Eichele, G. 1990. Nature 345, 815.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-October-2007 RFH
SynonymsTretinoin, ATRA, Vitamin A Acid
DescriptionPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number302-79-4
RTECSVH6475000
Chemical formulaC₂₀H₂₈O₂
Structure formulaStructure formula
Purity≥95% by assay
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 8165
ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
Labbaye, C., et al. 1993. Blood 81, 475.
Sakashita, A., et al. 1993. Blood 81, 1009.
Situ, R., et al. 1993. Dermatology 186, 38.
Tini, M., et al. 1993. Genes Develop. 7, 295.
Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
Sharpe, C.R. 1991. Neuron 7, 239.
Thaller, C. and Eichele, G. 1990. Nature 345, 815.