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525145 sPLA₂-IIA Inhibitor I - Calbiochem

The sPLA₂-IIA Inhibitor I controls the biological activity of sPLA₂-IIA. This small molecule/inhibitor is primarily used for Cell Signaling applications.

sPLA₂-IIA Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: c(2NapA)LS(2NapA)R, TFA

Primary Target: sPLA2-IIA (human type IIA secreted phospholipase A2
525145
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₄₁H₅₀N₈O₆ · CF₃CO₂H

Products

Catalogue NumberPackaging Qty/Pack
525145-1MGCN Plastic ampoule 1 mg
Description
OverviewA highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA2-IIA (human type IIA secreted phospholipase A2; IC50 = 12.8 μM). Shown to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA even at 10 μM concentration.
Catalogue Number525145
Brand Family Calbiochem®
Synonymsc(2NapA)LS(2NapA)R, TFA
References
ReferencesChurch, W.B., et al. 2001. J. Biol. Chem. 276, 33156.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
Chemical formulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetsPLA2-IIA (human type IIA secreted phospholipase A2
Primary Target IC<sub>50</sub>12.8 µM against sPLA2-IIA (human type IIA secreted phospholipase A2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide Sequencecyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
525145-1MGCN 04055977197136

Documentation

sPLA₂-IIA Inhibitor I - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

sPLA₂-IIA Inhibitor I - Calbiochem Certificates of Analysis

TitleLot Number
525145

References

Reference overview
Church, W.B., et al. 2001. J. Biol. Chem. 276, 33156.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-August-2008 RFH
Synonymsc(2NapA)LS(2NapA)R, TFA
DescriptionA highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of human type IIA secreted phospholipase A2 (sPLA2-IIA) (IC50 = 12.8 µM). Reported to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 µM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA at 10 µM.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
Peptide Sequencecyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesChurch, W.B., et al. 2001. J. Biol. Chem. 276, 33156.