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506106 p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem

The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,2ʹ-Dihydroxy-1,1ʹ-dinaphthyldisulfide, PAK Inhibitor III

506106
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
42521-82-4C₂₀H₁₄O₂S₂

Products

Catalogue NumberPackaging Qty/Pack
506106-25MGCN Plastic ampoule 25 mg
506106-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable symmetrical disulfide allosteric inhibitor that selectively targets the autoregulatory domain of group I, but not group II, PAKs (p21-activated kinases) and prevents the activation of PAK1/2/3 (% inhibition= 95, 70, and 60, respectively, with 10 µM inhibitor; IC50 = 2.5 µM for PAK1). Specificity test shows ≥ 50% inhibition, in the presence of 10 µM ATP and inhibitor, against 9 of 214 non-PAK human kinases. Shown to effectively suppress both basal and PDGF-induced PAK activation at 30 µM in mouse embryonic fibroblasts. IPA-3 does not inhibit the enzymatic activity of preactivated PAKs and reduction of the intramolecular disulfide bond of IPA-3 by DTT renders it inactive.
Catalogue Number506106
Brand Family Calbiochem®
Synonyms2,2ʹ-Dihydroxy-1,1ʹ-dinaphthyldisulfide, PAK Inhibitor III
References
ReferencesDeacon, S.W., et al. 2008. Chem. Biol. 15, 322.
Product Information
CAS number42521-82-4
FormYellow solid
Hill FormulaC₂₀H₁₄O₂S₂
Chemical formulaC₂₀H₁₄O₂S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
506106-25MGCN 04055977199413
506106-5MGCN 07790788050863

Documentation

p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem Certificates of Analysis

TitleLot Number
506106

References

Reference overview
Deacon, S.W., et al. 2008. Chem. Biol. 15, 322.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms2,2ʹ-Dihydroxy-1,1ʹ-dinaphthyldisulfide, PAK Inhibitor III
DescriptionA cell-permeable symmetrical disulfide allosteric inhibitor that selectively targets the autoregulatory domain of group I, but not group II, PAKs (p21-activated kinases) and prevents the activation of PAK1/2/3 (% inhibition= 95, 70, and 60, respectively, with 10 µM inhibitor; IC50 = 2.5 µM for PAK1). Specificity test shows ≥ 50% inhibition, in the presence of 10 µM ATP and inhibitor, against 9 of 214 non-PAK human kinases. Shown to effectively suppress both basal and PDGF-induced PAK activation at 30 µM in mouse embryonic fibroblasts. IPA-3 does not inhibit the enzymatic activity of preactivated PAKs and reduction of the intramolecular disulfide bond of IPA-3 by DTT renders it inactive.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number42521-82-4
Chemical formulaC₂₀H₁₄O₂S₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (2 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity Irritant
ReferencesDeacon, S.W., et al. 2008. Chem. Biol. 15, 322.