324517 Sigma-AldricheIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation.
More>> eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation. Less<<Synonyms: 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
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Overview
Key Spec Table
CAS # | Empirical Formula |
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315706-13-9 | C₁₈H₁₂Cl₂N₄O₄S |
Products
Catalogue Number | Packaging | Qty/Pack | |
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324517-10MGCN | Plastic ampoule | 10 mg |
Description | |
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Overview | A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519). |
Catalogue Number | 324517 |
Brand Family | Calbiochem® |
Synonyms | 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I |
References | |
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References | Moerke, N. J., et al. 2007. Cell 128, 257. |
Product Information | |
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CAS number | 315706-13-9 |
Form | Yellow solid |
Hill Formula | C₁₈H₁₂Cl₂N₄O₄S |
Chemical formula | C₁₈H₁₂Cl₂N₄O₄S |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
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Application | eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation. |
Biological Information | |
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Purity | ≥98% by HPLC (sum of two isomers) |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
324517-10MGCN | 04055977197327 |