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681674 Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem

The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI

681674
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
305372-78-5C₂₁H₁₈ClN₃

Products

Catalogue NumberPackaging Qty/Pack
681674-5MGCN Glass bottle 5 mg
Description
OverviewA cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
Catalogue Number681674
Brand Family Calbiochem®
SynonymsCCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
References
ReferencesEwan, K., et al. 2010. Cancer Res. 70, 5963.
Product Information
CAS number305372-78-5
FormOff-white solid
Hill FormulaC₂₁H₁₈ClN₃
Chemical formulaC₂₁H₁₈ClN₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by 1H NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
681674-5MGCN 04055977225228

Documentation

Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem Certificates of Analysis

TitleLot Number
681674

References

Reference overview
Ewan, K., et al. 2010. Cancer Res. 70, 5963.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-March-2012 JSW
SynonymsCCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
DescriptionA cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number305372-78-5
Chemical formulaC₂₁H₁₈ClN₃
Structure formulaStructure formula
Purity≥95% by 1H NMR
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesEwan, K., et al. 2010. Cancer Res. 70, 5963.