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681665 Wnt Agonist - CAS 853220-52-7 - Calbiochem

Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).

Wnt Agonist - CAS 853220-52-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I

Primary Target: Selective activator of Wnt signaling
681665
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
853220-52-7C₁₉H₁₈N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
681665-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC50 > 60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).
Catalogue Number681665
Brand Family Calbiochem®
Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
References
ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
Product Information
CAS number853220-52-7
ATP CompetitiveN
FormYellowish sticky solid
Hill FormulaC₁₉H₁₈N₄O₃
Chemical formulaC₁₉H₁₈N₄O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationWnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).
Biological Information
Primary TargetSelective activator of Wnt signaling
Primary Target IC<sub>50</sub>EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
681665-5MGCN 04055977260236

Documentation

Wnt Agonist - CAS 853220-52-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Wnt Agonist - CAS 853220-52-7 - Calbiochem Certificates of Analysis

TitleLot Number
681665

References

Reference overview
Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
DescriptionA cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50 >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development.
FormYellowish sticky solid
Intert gas (Yes/No) Packaged under inert gas
CAS number853220-52-7
Chemical formulaC₁₉H₁₈N₄O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.