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582243 Tetanus Toxin, Clostridium tetani - CAS 676570-37-9 - Calbiochem

Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
582243
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Overview

Replacement Information

Key Spec Table

CAS #
676570-37-9

Products

Catalogue NumberPackaging Qty/Pack
582243-25UGCN Alu drum 25 μg
Description
OverviewProduced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
Catalogue Number582243
Brand Family Calbiochem®
References
ReferencesMontecucco, C., et al. 1994. FEBS Lett. 346, 92.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
Product Information
CAS number676570-37-9
ATP CompetitiveN
FormLyophilized
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Biological activityBinds GT1b ganglioside in a hemagglutination assay
Primary TargetTetanus toxin is one of the deadliest toxins known
PuritySingle band by SDS-PAGE
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXW5807000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 45

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
582243-25UGCN 04055977265699

Documentation

Tetanus Toxin, Clostridium tetani - CAS 676570-37-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Tetanus Toxin, Clostridium tetani - CAS 676570-37-9 - Calbiochem Certificates of Analysis

TitleLot Number
582243

References

Reference overview
Montecucco, C., et al. 1994. FEBS Lett. 346, 92.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.

Citations

Title
  • Jerome Vicogne, et al. (2006) Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Procedings of the National Academy of Science 103, 14761-14766.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision22-January-2009 JSW
    DescriptionProduced by the anaerobic bacillus Clostridium tetani, Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (~100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (~50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
    FormLyophilized
    CAS number676570-37-9
    RTECSXW5807000
    PuritySingle band by SDS-PAGE
    Biological activityBinds GT1b ganglioside in a hemagglutination assay
    SolubilityPlease refer to the vial label for lot-specific reconstitution volume.
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
    Toxicity Highly Toxic
    ReferencesMontecucco, C., et al. 1994. FEBS Lett. 346, 92.
    Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
    Citation
  • Jerome Vicogne, et al. (2006) Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Procedings of the National Academy of Science 103, 14761-14766.
    		•