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654255 TNF-α Antagonist - Calbiochem

The TNF-α Antagonist controls the biological activity of TNF-α.

TNF-α Antagonist - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I

Primary Target: TNF-α
654255
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅₈H₇₁N₁₁O₁₅S₂

Products

Catalogue NumberPackaging Qty/Pack
654255-1MGCN Plastic ampoule 1 mg
Description
OverviewAn exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.
Catalogue Number654255
Brand Family Calbiochem®
SynonymsTNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
References
ReferencesTakasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
Product Information
ATP CompetitiveN
DeclarationSold under license of U.S. Patent 6,265,535.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₅₈H₇₁N₁₁O₁₅S₂
Chemical formulaC₅₈H₇₁N₁₁O₁₅S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-α
Primary Target IC<sub>50</sub>5 µM as TNF-α antagonist
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
654255-1MGCN 04055977184624

Documentation

TNF-α Antagonist - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TNF-α Antagonist - Calbiochem Certificates of Analysis

TitleLot Number
654255

References

Reference overview
Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-November-2013 JSW
SynonymsTNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
DescriptionAn exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Chemical formulaC₅₈H₇₁N₁₁O₁₅S₂
Peptide SequenceH-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
Purity≥95% by HPLC
SolubilityH₂O (1 mg/ml) or 5% Acetic Acid (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
Toxicity Standard Handling
ReferencesTakasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.