505156 MilliporeSUMOylation Inhibitor III, 2-D08 - Calbiochem
A cell-permeable compound that prevents the transfer of SUMO from the E2 thioester to the substrate without affecting SUMO-activating enzyme E1 (SAE-1/2) or E2 Ubc9-SUMO thioester formation.
More>> A cell-permeable compound that prevents the transfer of SUMO from the E2 thioester to the substrate without affecting SUMO-activating enzyme E1 (SAE-1/2) or E2 Ubc9-SUMO thioester formation. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one, 2D08, SUMO E2 Ubc9 Inhibitor
Recommended Products
Overview
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Key Spec Table
| Empirical Formula |
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| C₁₅H₁₀O₅ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 5.05156.0001 | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable trihydroxyflavone compound that prevents the transfer of SUMO (Cat. Nos. 662037, 662039, and 662042) from the E2 thioester to the substrate without affecting SUMO-activating enzyme E1 (SAE-1/2; Cat. Nos. 662073 and 662074) or E2 Ubc9-SUMO thioester formation. A 6 h pretreatment with 100 µM 2-D08 is shown to effectively inhibit 10 µM CPT- (Camptothecin; Cat. No. 208925) induced Topoisomerase I SUMOylation in breast cancer ZR-75-1 and BT-474 cultures without affecting overall cellular protein ubiquitinations. Anacardic and Ginkgolic Acid (Cat. No. 172050 and 345887, respectively) in comparison, both inhibit E1-SUMO thioester formation instead. |
| Catalogue Number | 505156 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one, 2D08, SUMO E2 Ubc9 Inhibitor |
| References | |
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| References | Kim, Y.S., et al. 2013. Chem. Biol. 20, 604. Cotelle, N., et al. 1996. Free Radic. Biol. Med. 20, 35. |
| Product Information | |
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| Form | Orange-brown powder |
| Hill Formula | C₁₅H₁₀O₅ |
| Chemical formula | C₁₅H₁₀O₅ |
| Reversible | Y |
| Quality Level | MQ300 |
| Applications |
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| Biological Information | |
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| Primary Target | SUMO E2-thioester complex |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 5.05156.0001 | 04055977263411 |
Documentation
SUMOylation Inhibitor III, 2-D08 - Calbiochem SDS
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SUMOylation Inhibitor III, 2-D08 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 505156 |
References
| Reference overview |
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| Kim, Y.S., et al. 2013. Chem. Biol. 20, 604. Cotelle, N., et al. 1996. Free Radic. Biol. Med. 20, 35. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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