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573125 STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem

The STAT3 Inhibitor IX, Cpd188, also referenced under CAS 823828-18-8, controls the biological activity of STAT3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-((3-(Carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid

573125
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
823828-18-8C₁₉H₁₅NO₇S₂

Products

Catalogue NumberPackaging Qty/Pack
573125-10MGCN 10 mg
Description
OverviewA cell-permeable naphthol compound that inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells (IC50 = 73 and 39 µM, respectively) by targeting STAT3 SH2 domain peptide-binding pocket (IC50 = 20 µM against EGFR-derived pY-peptide binding), while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation even at concentrations as high as 300 µM. Shown to preferentially induce apoptosis in cultures expressing constitutively active STAT3 (EC50 = 0.73, 3.96, and 7.01 µM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively), while being less effective against cells without constitutively active STAT3 (EC50 = 15.5 and 17.19 µM in MDA-MB-453 and MCF7 cultures, respectively).
Catalogue Number573125
Brand Family Calbiochem®
Synonyms4-((3-(Carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid
References
ReferencesXu, X., et al. 2009. PLoS One 4, e4783.
Product Information
CAS number823828-18-8
FormBeige solid
Hill FormulaC₁₉H₁₅NO₇S₂
Chemical formulaC₁₉H₁₅NO₇S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573125-10MGCN 04055977266061

Documentation

STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem Certificates of Analysis

TitleLot Number
573125

References

Reference overview
Xu, X., et al. 2009. PLoS One 4, e4783.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-April-2024 JSW
Synonyms4-((3-(Carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid
DescriptionA cell-permeable naphthol compound that inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells (IC50 = 73 and 39 µM, respectively) by targeting STAT3 SH2 domain peptide-binding pocket (IC50 = 20 µM against EGFR-derived pY-peptide binding), while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation even at concentrations as high as 300 µM. Shown to preferentially induce apoptosis in cultures expressing constitutively active STAT3 (EC50 = 0.73, 3.96, and 7.01 µM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively), while being less effective against cells without constitutively active STAT3 (EC50 = 15.5 and 17.19 µM in MDA-MB-453 and MCF7 cultures, respectively).
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number823828-18-8
Chemical formulaC₁₉H₁₅NO₇S₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesXu, X., et al. 2009. PLoS One 4, e4783.