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531371 S1P Receptor 2 Agonist, CYM-5520 - CAS 1449747-00-5 - Calbiochem

A potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC₅₀ = 480 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: S1PR2 Agonist, CYM-5520, Sphingosine-1-Phosphate Receptor 2 Agonist, CYM 5520, EDG5 Agonist

Primary Target: S1PR2
531371
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1449747-00-5C₂₁H₁₉N₃O₂

Products

Catalogue NumberPackaging Qty/Pack
5.31371.0001 Glass bottle 10 mg
Description
OverviewA pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. Does not affect the activity of S1PR1, 3, and 5 and the activity of 29 other receptors and transports in any significant manner. Acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531371
Brand Family Calbiochem®
SynonymsS1PR2 Agonist, CYM-5520, Sphingosine-1-Phosphate Receptor 2 Agonist, CYM 5520, EDG5 Agonist
References
ReferencesSatsu, H., et al. 2013. Bioorg. Med. Chem. 21, 5373.
Product Information
CAS number1449747-00-5
FormOff-white solid
Hill FormulaC₂₁H₁₉N₃O₂
Chemical formulaC₂₁H₁₉N₃O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetS1PR2
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.31371.0001 04055977260298

Documentation

S1P Receptor 2 Agonist, CYM-5520 - CAS 1449747-00-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Satsu, H., et al. 2013. Bioorg. Med. Chem. 21, 5373.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2014 JSW
SynonymsS1PR2 Agonist, CYM-5520, Sphingosine-1-Phosphate Receptor 2 Agonist, CYM 5520, EDG5 Agonist
DescriptionA pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. Does not affect the activity of S1PR1, 3, and 5 and the activity of 29 other receptors and transports in any significant manner. Acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1449747-00-5
Chemical formulaC₂₁H₁₉N₃O₂
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).
Toxicity Standard Handling
ReferencesSatsu, H., et al. 2013. Bioorg. Med. Chem. 21, 5373.