554328 Sigma-AldrichResveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem
A cell-permeable triacetate resveratrol prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures.
More>> A cell-permeable triacetate resveratrol prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: trans-3,5,4ʹ-Triacetylstilbene, 3,5,4ʹ-Tri-O-acetylresveratrol
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 42206-94-0 | C₂₀H₁₈O₈ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 554328-25MGCN | Glass bottle | 25 mg |
| Description | |
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| Overview | A cell-permeable triacetate resveratrol (Cat. No. 554325) prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures. Cremophor EL is reported to protect the prodrug from fast hydrolysis and resveratrol conversion in mouse serum at 37°C (100% conversion within 20 sec vs. >300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 µM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all). |
| Catalogue Number | 554328 |
| Brand Family | Calbiochem® |
| Synonyms | trans-3,5,4ʹ-Triacetylstilbene, 3,5,4ʹ-Tri-O-acetylresveratrol |
| References | |
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| References | Koide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270. Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732. |
| Product Information | |
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| CAS number | 42206-94-0 |
| Form | White powder |
| Hill Formula | C₂₀H₁₈O₈ |
| Chemical formula | C₂₀H₁₈O₈ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Purity | ≥97% by HPLC |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 554328-25MGCN | 04055977193060 |
Documentation
Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem SDS
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Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 554328 |
References
| Reference overview |
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| Koide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270. Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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