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559286 RSK Inhibitor II - CAS 501437-28-1 - Calbiochem

559286
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Overview

Key Spec Table

CAS #Empirical Formula
501437-28-1C₁₉H₂₃F₂N₅O₂

Products

Catalogue NumberPackaging Qty/Pack
559286-5MGCN Glass bottle 5 mg
Description
OverviewThe racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC50 ≤31 nM against RSK1, 2, 3, and 4; [ATP] = 100 µM) by targeting RSK N-terminal kinase domain in an ATP-competitive manner, while inhibiting 11 other kinases only at higher concentrations (IC50 ≥100 nM) and displaying little activity against 39 others. Shown to selectively inhibit RSK-dependent, but not RSK-independent, cellular protein phosphorylations in PMA-stimulated HEK-293 cells and EGF-stimulated Rat-2 cells (IC50 ~1 µM).
Catalogue Number559286
Brand Family Calbiochem®
Synonyms2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870
References
ReferencesCarriere, A., et al. 2008. Curr. Biol. 18, 1269
Sapkota, G.P., et al. 2007. Biochem. J. 401, 29.
Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.
Product Information
CAS number501437-28-1
FormOff-white solid
Hill FormulaC₁₉H₂₃F₂N₅O₂
Chemical formulaC₁₉H₂₃F₂N₅O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
559286-5MGCN 04055977192377