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554995 RGS Proteins Inhibitor II, CCG-50014 - Calbiochem

554995
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Overview

Key Spec Table

Empirical Formula
C₁₆H₁₃FN₂O₂S

Products

Catalogue NumberPackaging Qty/Pack
554995-10MGCN Glass bottle 10 mg
Description
OverviewA cell-permeable thiadiazolidinedione compound that acts as a direct, potent, selective and cysteine-reactive irreversible inhibitor of RGS4 over other RGS proteins (IC50 = 0.03, 0.12, 3.5, 11, > 200 and > 200 µM against RGS4, RGS19, RGS16, RGS8, RGS7 and RGS4Cys using FCPIA assay, respectively). Shown to block RGS4-Gα0 interaction and repress Gα0-dependent membrane localization of RGS4 in HEK-293T cells with no effect on the intrinsic rate of GTP hydrolysis by Gα0. Suggested to interact with Cys107-RGS8 allosteric regulatory site and display minimal affinity towards papain (IC50 > 100 µM). A reversible inhibitor of RGS Proteins, CCG-63802 is also available (Cat. No. 554993).
Catalogue Number554995
Brand Family Calbiochem®
Synonyms4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione
References
ReferencesBlazer, L.L., et al. 2011. Biochemistry 50, 3181.
Roman, D.L., et al. 2009. J. Biomol. Screening 14, 610.
Product Information
FormWhite solid
Hill FormulaC₁₆H₁₃FN₂O₂S
Chemical formulaC₁₆H₁₃FN₂O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
554995-10MGCN 04055977268362