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554718 REV-ERBα Antagonist, SR8278 - CAS 101910-24-1 - Calbiochem

The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SR8278 SR 8278

554718
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
101910-24-1C₁₈H₁₉NO₃S₂

Products

Catalogue NumberPackaging Qty/Pack
554718-5MGCN Glass bottle 5 mg
Description
OverviewA cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
Catalogue Number554718
Brand Family Calbiochem®
SynonymsSR8278 SR 8278
References
ReferencesKojetin, D., et al. 2010, Chem Bio in press
Product Information
CAS number101910-24-1
FormWhite to yellow-brown solid or gum
Hill FormulaC₁₈H₁₉NO₃S₂
Chemical formulaC₁₈H₁₉NO₃S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity>95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
554718-5MGCN 04055977193114

Documentation

REV-ERBα Antagonist, SR8278 - CAS 101910-24-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

REV-ERBα Antagonist, SR8278 - CAS 101910-24-1 - Calbiochem Certificates of Analysis

TitleLot Number
554718

References

Reference overview
Kojetin, D., et al. 2010, Chem Bio in press
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-February-2020 JSW
SynonymsSR8278 SR 8278
DescriptionA cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
FormWhite to yellow-brown solid or gum
Intert gas (Yes/No) Packaged under inert gas
CAS number101910-24-1
Chemical formulaC₁₈H₁₉NO₃S₂
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Toxicity Regulatory Review
ReferencesKojetin, D., et al. 2010, Chem Bio in press