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554718 REV-ERBα Antagonist, SR8278 - CAS 101910-24-1 - Calbiochem

554718
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Overview

Key Spec Table

CAS #Empirical Formula
101910-24-1C₁₈H₁₉NO₃S₂

Products

Catalogue NumberPackaging Qty/Pack
554718-5MGCN Glass bottle 5 mg
Description
OverviewA cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
Catalogue Number554718
Brand Family Calbiochem®
SynonymsSR8278 SR 8278
References
ReferencesKojetin, D., et al. 2010, Chem Bio in press
Product Information
CAS number101910-24-1
FormWhite to yellow-brown solid or gum
Hill FormulaC₁₈H₁₉NO₃S₂
Chemical formulaC₁₈H₁₉NO₃S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity>95% by HPLC
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
554718-5MGCN 04055977193114