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554726 REV-ERB Agonist II, SR9009 - Calbiochem

REV-ERB Agonist II, SR9009, CAS 1379686-30-2, acts as a specific REV-ERB-α/β agonist that exhibits a direct and reversible binding (Kd = 800 nM).

REV-ERB Agonist II, SR9009 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate

Primary Target: REV-ERB-α/&beta
554726
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1379686-30-2C₂₀H₂₄ClN₃O₄S

Products

Catalogue NumberPackaging Qty/Pack
554726-25MGCN Glass bottle 25 mg
Description
OverviewA pyrrolidinecarbamate compound that acts as a specific REV-ERB-α/β agonist. Exhibits a direct and reversible binding (Kd = 800 nM REV-ERB-α) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800 nM in Gal4-REV-ERB-α and β transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710 nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100 mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern.
Catalogue Number554726
Brand Family Calbiochem®
SynonymsEthyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate
References
ReferencesSolt, L.A., et al. 2012. Nature 485, 62.
Product Information
CAS number1379686-30-2
FormDark brown liquid
Hill FormulaC₂₀H₂₄ClN₃O₄S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationREV-ERB Agonist II, SR9009, CAS 1379686-30-2, acts as a specific REV-ERB-α/β agonist that exhibits a direct and reversible binding (Kd = 800 nM).
Biological Information
Primary TargetREV-ERB-α/&beta
Purity≥96% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
554726-25MGCN 04055977193145

Documentation

REV-ERB Agonist II, SR9009 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

REV-ERB Agonist II, SR9009 - Calbiochem Certificates of Analysis

TitleLot Number
554726

References

Reference overview
Solt, L.A., et al. 2012. Nature 485, 62.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-November-2012 JSW
SynonymsEthyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate
DescriptionA pyrrolidinecarbamate compound that acts as a specific REV-ERB-α/β agonist. Exhibits a direct and reversible binding (Kd = 800 nM REV-ERB-α) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800 nM in Gal4-REV-ERB-α and β transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710 nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100 mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern.
FormDark brown liquid
Intert gas (Yes/No) Packaged under inert gas
CAS number1379686-30-2
Structure formulaStructure formula
Purity≥96% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSolt, L.A., et al. 2012. Nature 485, 62.