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Prostak™ Microfiltration Modules

Membrane-based separations device in Prostak™ Tangential Flow Filter (TFF) Systems. More

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Overview

Specifications

Ordering Information

Durapore® Hydrophilic MembraneClear Sorting & Filtering Show Filter Hide Filter
Catalogue Number	Filter Code	Pore Size	Device Size
PSVVAG021	VVPP	0.1 µm	2 stack
PSVVAG041	VVPP	0.1 µm	4 stack
PSVVAG101	VVPP	0.1 µm	10 stack
PSGVAG021	GVPP	0.22 µm	2 stack
PSGVAG041	GVPP	0.22 µm	4 stack
PSGVAG101	GVPP	0.22 µm	10 stack
PSHVAG021	HVMP	0.45 µm	2 stack
PSHVAG041	HVMP	0.45 µm	4 stack
PSHVAG101	HVMP	0.45 µm	10 stack
PSDVAG021	DVPP	0.65 µm	2 stack
PSDVAG041	DVPP	0.65 µm	4 stack
PSDVAG101	DVPP	0.65 µm	10 stack
SK2P484E0	GVPP	0.22 µm	20 stack

HolderClear Sorting & Filtering Show Filter Hide Filter
Catalogue Number	Description	Pack Size
PSKPMF001	Prostak™ OPEN CHANNEL HOLDER	1

Documentation

Related Products & Applications

Categories

Biopharmaceutical Manufacturing > Upstream Processing > Cell Culture > Cell Culture Clarification > Millistak+ Pod > Prostak

C564Membrane-based separations device in Prostak™ Tangential Flow Filter (TFF) Systems.

Description

Prostak™ microfiltration modules are tangential flow filtration devices in a stacked plate configuration with open feed channels. A microporous membrane, Durapore® polyvinylidene fluoride (PVDF), is bonded on both sides of each plate. The plates are then stacked in parallel forming stacks. Prostak™ microfiltration open-channel modules are available in four sizes: 2, 4, 10 and 20 stacks, making them applicable for bench-top, pilot, and production scale systems.

The modules can be integrity tested and steam sterilized for 20 cycles.

Prostak™ MF modules must be used with a support holder, which controls deflection and provides sanitary fittings for connection to external piping. Sanitary gaskets supplied with the module provide a leak-free connection between the module(s) and the holder.

Typical Applications

Prostak™ microfiltration is used for separations where viscosity and suspended solids levels of the feed stream require an open feed channel. They are typically used in perfusion applications or in the clarification/harvest of:

Mammalian, bacterial and mycelial cell suspensions
Emulsions and colloidal suspension
Viruses, proteins and other bio-organic macromolecular solutions
Polysaccharides and other high viscosity solutions
Yeast, algae, and other high solids suspensions
Protein precipitate
Vaccines

Physical Specifications
	2 Stacks	4 Stacks	10 Stacks	20 Stacks
Dry Weight	1.6 kg (3.5 lbs)	2.1 kg (4.6 lbs)	3.6 kg (7.9 lbs)	6.2 kg (13.7 lbs)
Length	38.9 cm (15.3 in.)	38.9 cm (15.3 in.)	38.9 cm (15.3 in.)	38.9 cm (15.3 in.)
Width	19.8 cm (7.8 in.)	19.8 cm (7.8 in.)	19.8 cm (7.8 in.)	19.8 cm (7.8 in.)
Height	4.6 cm (1.8 in.)	5.6 cm (2.2 in.)	8.1 cm (3.2 in.)	12.4 cm (4.9 in.)
Total Internal Volume	500 ml	700 ml	1250 ml	2500 ml
Feed Internal Volume	300 ml	420 ml	750 ml	1500 ml
Filtrate Internal Volume	200 ml	280 ml	500 ml	1000 ml
Membrane Area	0.17 m²	0.33 m²	0.84 m²	1.7 m²

Materials of Construction
Membrane	Hydrophilic or Hydrophobic Durapore® (PVDF)
Plates and End Caps	Polysulfone, 10% glass filled
Sanitary Gaskets	Silicone
Operating Guidelines
Prefiltration Required	150 µm
Maximum Inlet Pressure
at < 50°C	5.6 bar (80 psi)*
at 50 - 80°C	4.2 bar (60 psi)
Maximum Transmembrane Pressure - Forward
at < 50°C	4.2 bar (60 psi)*
at 50 - 80°C	2.1 bar (30 psi)
pH Range
short duration (1 hr cycle)	1 - 11 (hydrophilic Durapore®) 1 - 13 (hydrophobic Durapore®)
continuous	2 – 10 (hydrophilic Durapore®) 2 – 12 (hydrophobic Durapore®)
Steaming (In Place)
Steam Pressure	20 psi
Cycle Time	1 hour
*Durapore® 0.65 µm membrane is 3.5 bar (50 psi) maximum forward pressure

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