Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

524390 Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem

524390
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
37558-16-0C₂₈H₄₀O₈

Products

Catalogue NumberPackaging Qty/Pack
524390-1MGCN Alu drum 1 mg
524390-5MGCN Alu drum 5 mg
Description
OverviewStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.
Catalogue Number524390
Brand Family Calbiochem®
SynonymsPDBu, PKC Activator II
References
ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
Lee, E.J., et al. 1994. Brain Res. 665, 127.
Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.
Product Information
CAS number37558-16-0
ATP CompetitiveN
FormWhite to light yellow solid
Hill FormulaC₂₈H₄₀O₈
Chemical formulaC₂₈H₄₀O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetNa+,K+- ATPase
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSEK7767000
Safety Information
R PhraseR: 26/27/28-36/37/38-40-41

Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Limited evidence of a carcinogenic effect.
Risk of serious damage to eyes.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
524390-1MGCN 04055977271546
524390-5MGCN 04055977271553