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530746 Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem

A cell-permeable nematicidal compound that covalently binds to the peroxidatic cysteine of peroxiredoxin II in T. gondii and irreversibly blocks its hyperperoxidation activity (IC₅₀ = 23 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor

Primary Target: Peroxiredoxin
530746
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
18080-67-6C₁₀H₈Br₂N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
5.30746.0001 Glass bottle 25 mg
Description
OverviewA cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530746
Brand Family Calbiochem®
Synonyms2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
References
ReferencesNguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.
Product Information
CAS number18080-67-6
FormYelllowish brown solid
Hill FormulaC₁₀H₈Br₂N₂O₂
Chemical formulaC₁₀H₈Br₂N₂O₂
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetPeroxiredoxin
Primary Target IC<sub>50</sub>23 µM for blocking TgPrxII hyperperoxidation activity
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.30746.0001 04055977242942

Documentation

Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Nguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-June-2014 JSW
Synonyms2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
DescriptionA cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.
FormYelllowish brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number18080-67-6
Chemical formulaC₁₀H₈Br₂N₂O₂
Purity≥95% by NMR
SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
Toxicity Standard Handling
ReferencesNguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.