529599 Sigma-AldrichPP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem
A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux in Syk MASA-expressing DT40 cells.
More>> A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux in Syk MASA-expressing DT40 cells. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 956026-24-7 | C₁₈H₂₃N₅ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 529599-10MGCN | Glass bottle | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable 3-MB-PP1 (Cat. No. 529582) analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1 µM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells. |
| Catalogue Number | 529599 |
| Brand Family | Calbiochem® |
| Synonyms | Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| References | |
|---|---|
| References | Miller, A.L., et al. 2009. J. Immunol. 182, 988. Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299. |
| Product Information | |
|---|---|
| CAS number | 956026-24-7 |
| Form | Off-white powder |
| Hill Formula | C₁₈H₂₃N₅ |
| Chemical formula | C₁₈H₂₃N₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 529599-10MGCN | 04055977269925 |
Documentation
PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 529599 |
References
| Reference overview |
|---|
| Miller, A.L., et al. 2009. J. Immunol. 182, 988. Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299. |
| Data Sheet | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|