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539695 PME-1 Inhibitor, AMZ-30 - Calbiochem

The PME-1 Inhibitor, AMZ-30 controls the biological activity of PME-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

PME-1 Inhibitor, AMZ-30 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile, NIH Probe ML136

539695
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₉H₁₃FN₃O₆S₂

Products

Catalogue NumberPackaging Qty/Pack
539695-10MGCN Glass bottle 10 mg
Description
OverviewA cell-permeable sulfonyl acrylonitrile compound that acts as a potent and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM and 2.5 µM in human cell lysates and in HEK 293T cells, respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20 µM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells.
Catalogue Number539695
Brand Family Calbiochem®
Synonyms(E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile, NIH Probe ML136
References
Product Information
FormYellow solid
Hill FormulaC₁₉H₁₃FN₃O₆S₂
Chemical formulaC₁₉H₁₃FN₃O₆S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
539695-10MGCN 04055977194234

Documentation

PME-1 Inhibitor, AMZ-30 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PME-1 Inhibitor, AMZ-30 - Calbiochem Certificates of Analysis

TitleLot Number
539695
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-August-2012 JSW
Synonyms(E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile, NIH Probe ML136
DescriptionA cell-permeable sulfonyl acrylonitrile compound that acts as a potent and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM and 2.5 µM in human cell lysates and in HEK 293T cells, (respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20 µM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₉H₁₃FN₃O₆S₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling