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528116 PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem

The PI 3-Kα Inhibitor VIII controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII

528116
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
372196-77-5C₁₆H₁₄N₅O₄SBr • HCl • 2H₂O

Products

Catalogue NumberPackaging Qty/Pack
528116-5MGCN Plastic Bag(s) 5 mg
Description
OverviewA cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
Catalogue Number528116
Brand Family Calbiochem®
SynonymsN-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII
References
ReferencesKim, S., et al. 2007. Blood 110, 4206.
Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
Knight, Z.A., et al. 2007. Cell 125, 733.
Product Information
CAS number372196-77-5
FormPale yellow solid
Hill FormulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
Chemical formulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528116-5MGCN 04055977196993

Documentation

PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem Certificates of Analysis

TitleLot Number
528116

References

Reference overview
Kim, S., et al. 2007. Blood 110, 4206.
Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
Knight, Z.A., et al. 2007. Cell 125, 733.

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
SynonymsN-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII
DescriptionA cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number372196-77-5
Chemical formulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesKim, S., et al. 2007. Blood 110, 4206.
Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
Knight, Z.A., et al. 2007. Cell 125, 733.