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528106 PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem

The PI 3-Kγ Inhibitor, also referenced under CAS 648450-29-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione, PI 3-K Inhibitor I

Primary Target: Phosphatidylinositol 3-kinase γ (PI 3-Kγ)
528106
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
648450-29-7C₁₂H₇N₃O₂S

Products

Catalogue NumberPackaging Qty/Pack
528106-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable thiazolidinedione compound that acts as a potent, selective, and ATP-competitive inhibitor of phosphatidylinositol 3-kinase γ (PI 3-Kγ) (Ki = 7.8 nM; IC50 = 8 nM, 60 nM, 270 nM, 300 nM for p110-γ, α, β and δ-isoforms, respectively). Does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 µM. Selectively blocks MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human monocytic cell line THP-1 (IC50 = 181 nM). Also shown to exhibit in vivo efficacy in reducing neutrophil chemotaxis in murine peritonitis and arthritis models.
Catalogue Number528106
Brand Family Calbiochem®
Synonyms5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione, PI 3-K Inhibitor I
References
ReferencesBarber, D.F., et al. 2005. Nat. Med. 11, 933.
Camps, M., et al. 2005. Nat. Med. 11, 936.
Product Information
CAS number648450-29-7
ATP CompetitiveY
FormPink solid
Hill FormulaC₁₂H₇N₃O₂S
Chemical formulaC₁₂H₇N₃O₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPhosphatidylinositol 3-kinase γ (PI 3-Kγ)
Primary Target IC<sub>50</sub>8 nM, 60 nM, 270 nM, 300 nM for p110-γ, α, β and δ-isoforms, respectively; 181 nM in selectively blocking MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human mono
Primary Target K<sub>i</sub>7.8 nM
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528106-5MGCN 04055977270495

Documentation

PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem Certificates of Analysis

TitleLot Number
528106

References

Reference overview
Barber, D.F., et al. 2005. Nat. Med. 11, 933.
Camps, M., et al. 2005. Nat. Med. 11, 936.

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-September-2007 JSW
Synonyms5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione, PI 3-K Inhibitor I
DescriptionA cell-permeable, potent, selective, and ATP-competitive inhibitor of phosphatidylinositol 3-kinase γ (PI 3-Kγ) (Ki = 7.8 nM; IC50 = 8 nM, 60 nM, 270 nM, 300 nM for p110-γ, α, β and δ-isoforms, respectively). Does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 µM. Selectively blocks MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human monocytic cell line THP-1 (IC50 = 181 nM). Also shown to exhibit in vivo efficacy in reducing neutrophil chemotaxis in murine peritonitis and arthritis models.
FormPink solid
Intert gas (Yes/No) Packaged under inert gas
CAS number648450-29-7
Chemical formulaC₁₂H₇N₃O₂S
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (2.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBarber, D.F., et al. 2005. Nat. Med. 11, 933.
Camps, M., et al. 2005. Nat. Med. 11, 936.