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499050 Osteocalcin, Bovine Bone

Osteocalcin, Bovine Bone MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Bone-Gla-Protein, BGP

499050
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
499050-100UGCN Plastic ampoule 100 μg
Description
OverviewSingle chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca2+ (Kd = 6 µM). Also binds hydroxylapatite. A good marker of bone turnover. May play a role in bone mineralization, bone resorption, and bone formation.
Catalogue Number499050
Brand Family Calbiochem®
SynonymsBone-Gla-Protein, BGP
References
ReferencesCarter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.
Product Information
FormLiquid
FormulationIn 75 mM NaCl, 10 mM sodium phosphate buffer, pH 7.4.
Hill FormulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
Chemical formulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
PI4.0 - 4.5
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by SDS-PAGE
Physicochemical Information
Peptide SequenceH-Tyr-Leu-Asp-His-Trp-Leu-Gly-Ala-Pro-Ala-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Lys-Arg-Gla-Val-Cys²³-Gla-Leu-Asn-Pro-Asp-Cys²⁹-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (disulfide bond: 23 → 29)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
499050-100UGCN 04055977199895

Documentation

Osteocalcin, Bovine Bone SDS

Title

Safety Data Sheet (SDS) 

Osteocalcin, Bovine Bone Certificates of Analysis

TitleLot Number
499050

References

Reference overview
Carter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
SynonymsBone-Gla-Protein, BGP
DescriptionSingle chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca2+ (Kd = 6 µM). Also binds hydroxylapatite. Possible role in bone mineralization, bone resorption, and bone formation. Note: Gla corresponds to γ-carboxyglutamic acid.
FormLiquid
FormulationIn 75 mM NaCl, 10 mM sodium phosphate buffer, pH 7.4.
Chemical formulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
Peptide SequenceH-Tyr-Leu-Asp-His-Trp-Leu-Gly-Ala-Pro-Ala-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Lys-Arg-Gla-Val-Cys²³-Gla-Leu-Asn-Pro-Asp-Cys²⁹-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (disulfide bond: 23 → 29)
Purity≥98% by SDS-PAGE
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesCarter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.