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492042 Nrf2 Activator III, TAT-14 Peptide - CAS 1362661-34-4 - Calbiochem

Nrf2 Activator III, TAT-14 Peptide, CAS 1362661-34-4, is a 14-mer peptide conjugated to cell-penetrating TAT sequence. Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

492042
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1362661-34-4C₁₃₇H₂₃₀N₄₈O₃₉

Products

Catalogue NumberPackaging Qty/Pack
492042-10MGCN Glass bottle 10 mg
Description
OverviewA 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-α secretion in THP-1 monocytes (~ 37.5 µM).
Catalogue Number492042
Brand Family Calbiochem®
SynonymsH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
References
ReferencesSteel, R., et al. 2012. ACS Med Chem Lett. 3, 407.
Product Information
CAS number1362661-34-4
FormWhite powder
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₃₇H₂₃₀N₄₈O₃₉
Chemical formulaC₁₃₇H₂₃₀N₄₈O₃₉
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
ApplicationNrf2 Activator III, TAT-14 Peptide, CAS 1362661-34-4, is a 14-mer peptide conjugated to cell-penetrating TAT sequence. Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
492042-10MGCN 04055977272789

Documentation

Nrf2 Activator III, TAT-14 Peptide - CAS 1362661-34-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Nrf2 Activator III, TAT-14 Peptide - CAS 1362661-34-4 - Calbiochem Certificates of Analysis

TitleLot Number
492042

References

Reference overview
Steel, R., et al. 2012. ACS Med Chem Lett. 3, 407.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-August-2012 JSW
SynonymsH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
DescriptionA 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-α secretion in THP-1 monocytes (~ 37.5 µM).
FormWhite powder
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
CAS number1362661-34-4
Chemical formulaC₁₃₇H₂₃₀N₄₈O₃₉
Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSteel, R., et al. 2012. ACS Med Chem Lett. 3, 407.