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349254 NS-398 - CAS 123653-11-2 - Calbiochem

A cell-permeable selective inhibitor of COX-2 in vitro.

NS-398 - CAS 123653-11-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide

Primary Target: COX-2
349254
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
123653-11-2C₁₃H₁₈N₂O₅S

Products

Catalogue NumberPackaging Qty/Pack
349254-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
Catalogue Number349254
Brand Family Calbiochem®
SynonymsN-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
References
ReferencesOuellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105.
Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.
Product Information
CAS number123653-11-2
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₃H₁₈N₂O₅S
Chemical formulaC₁₃H₁₈N₂O₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-2
Primary Target IC<sub>50</sub>3.8 µM against COX-2
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
349254-5MGCN 04055977193213

Documentation

NS-398 - CAS 123653-11-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NS-398 - CAS 123653-11-2 - Calbiochem Certificates of Analysis

TitleLot Number
349254

References

Reference overview
Ouellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105.
Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-July-2008 RFH
SynonymsN-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
DescriptionA cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC50 = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes.
FormPale yellow solid
CAS number123653-11-2
Chemical formulaC₁₃H₁₈N₂O₅S
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (20 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesOuellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105.
Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.