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454586 NMDAR2C/2D Inhibitor, DQP-1105 - CAS 380560-89-4 - Calbiochem

The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DQP-1105, NMDA Antagonist IV

454586
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
380560-89-4C₂₉H₂₄BrN₃O₄

Products

Catalogue NumberPackaging Qty/Pack
454586-10MGCN Glass bottle 10 mg
Description
OverviewA dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.
Catalogue Number454586
Brand Family Calbiochem®
SynonymsDQP-1105, NMDA Antagonist IV
References
ReferencesAcker, T., et al. 2011. Mol. Pharmacol. 80, 782.
Product Information
CAS number380560-89-4
FormYellow-white solid
Hill FormulaC₂₉H₂₄BrN₃O₄
Chemical formulaC₂₉H₂₄BrN₃O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
454586-10MGCN 04055977204193

Documentation

NMDAR2C/2D Inhibitor, DQP-1105 - CAS 380560-89-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NMDAR2C/2D Inhibitor, DQP-1105 - CAS 380560-89-4 - Calbiochem Certificates of Analysis

TitleLot Number
454586

References

Reference overview
Acker, T., et al. 2011. Mol. Pharmacol. 80, 782.

Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-May-2012 JSW
SynonymsDQP-1105, NMDA Antagonist IV
DescriptionA dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.
FormYellow-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number380560-89-4
Chemical formulaC₂₉H₂₄BrN₃O₄
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml; pale yellow solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesAcker, T., et al. 2011. Mol. Pharmacol. 80, 782.